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CompletedNCT06958510Updated Dec 31, 2025

Modified Anatomical Mesh In The Management Of Orbito-Zygomatico-Maxillary Complex Fractures

An interventional study of 3D-Modified Anatomical-Mesh. and conventional orbital rim miniplates and orbital mesh configuration in Orbital Fractures and Zygomatic Fractures, sponsored by Alexandria University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-31.

Sponsored by Alexandria University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
24
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Orbito-Zygomaticomaxillary-complex fractures is a form of a complex orbital floor fracture, with affection of the inferior orbital rim and the orbital walls. According to published research, between 67 - 84 % of periorbital bone fractures are orbital floor fractures.

Evaluation of 3D-Modified Anatomic Mesh in the management of OZM- complex fractures with orbital floor defect, and compare it with the conventional fixation configuration.

Read the detailed description

Patients suffering from OZM- complex fractures was treated using 3D-Modified Anatomical Mesh for orbital floor reconstruction and orbital rim fixation. Patients was randomly allocated into study and control groups, where it is managed with the conventional 2.0-miniplate and stock mesh. A standardized surgical protocol was followed in both groups. Patients was clinically evaluated for pain, wound healing, nerve sensation, ocular motility and diplopia, and tarsal plate morphology. Moreover, radiographic survey was performed post operatively to assess the proper positioning of the implant, to confirm proper fracture reduction, and radiographic enophthalmos analysis

02

Conditions studied

  • Orbital Fractures
  • Zygomatic Fractures

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Keywords

  • anatomical mesh
  • 3D-mesh
  • orbital mesh
  • orbital fracture
  • zygomatic fracture
  • reconstruction
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Patients suffering from Orbito-Zygomaticomaxillary complex fractures with fracture in the orbital floor and orbital floor defect(16).
  2. Fractures that are indicated for open reduction and internal fixation.
  3. Patients suffering from ocular complications:

    1. Monocular diplopia.
    2. Enophthalmos above 2 mm.
    3. Restricted ocular motility.
  4. Patients with orbital wall defects with orbital soft tissue herniation into the maxillary sinus.
  5. Adult patient either male or female that agrees to present for follow-up visits for an adequate postoperative period.

Exclusion criteria

Exclusion Criteria:

  1. Patients with isolated orbital floor defects and blowout fractures.
  2. Patients with isolated zygomatico-maxillary complex fracture with no orbital floor/ walls defects.
  3. Patients with bilateral orbital defects.
  4. Patients with Infected wounds in periorbital region.
  5. Medically compromised patients rendering them inoperable.
  6. Patients with ruptured globe or blindness.
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
24 participants (actual)

Study arms

  • Active comparator
    Patients with Orbito-Zygomaticomaxillary Complex fracture managed with 3D-Modified Anatomical-Mesh

    Patients with Orbito-Zygomaticomaxillary Complex fracture managed with 3D-Modified Anatomical-Mesh

    Device: 3D-Modified Anatomical-Mesh.

  • Experimental
    Patients with Orbito-Zygomaticomaxillary Complex fracture managed with conventional orbital rim mini

    Patients with Orbito-Zygomaticomaxillary Complex fracture managed with conventional orbital rim mini

    Device: conventional orbital rim miniplates and orbital mesh configuration

Interventions

  • Device3D-Modified Anatomical-Mesh.

    3D-Modified Anatomical-Mesh.

  • Deviceconventional orbital rim miniplates and orbital mesh configuration

    conventional orbital rim miniplates and orbital mesh configuration

05

What researchers measure

Primary outcomes

  1. Radiographic assessment of the management of the Orbito-Zygomaticomaxillary Complex fracture

    Radiographic assessment of the management of the Orbito-Zygomaticomaxillary Complex fracture

    Time frame: 1 week

Secondary outcomes

  1. Periorbital ecchymosis

    Postoperative periorbital ecchymosis will be evaluated on a 3-points scale (0-3). The scoring system divides ecchymosis into upper and lower eyelids, and furthermore into thirds for each eyelid.

    Time frame: 6 weeks

06

Study locations

1 site
  • Faculty of Dentistry, Alexandria University
    Alexandria, Alexandria Governorate 21523, Egypt
07

References and documents

Individual participant data

Plan to share: Yes — all data will be de-identified to protect the participant data. patients signed an informed consent for the use of their medical records and data for study

Supporting information: Sap

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT06958510
Lead sponsor
Alexandria University
Responsible party
Sponsor
First posted
May 6, 2025
Start date
Oct 1, 2024
Primary completion
Mar 1, 2025
Completion
Jun 15, 2025
Last update
Dec 31, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
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