A Phase 1 interventional study of Ondansetron (Zofran) and chewing gum in Postoperative Nausea and Vomiting (PONV), sponsored by Makassed General Hospital. Active, not recruiting at 1 site in Lebanon. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-10-01.
Sponsored by Makassed General Hospital · Phase 1, Interventional, and Treatment
The proposed randomized clinical trial aims to test and compare the efficacy of chewing gum vs. Intravenous antiemetic ondansetron as rescue treatment for post-operative nausea and vomiting (PONV) among Lebanese female patients undergoing laparoscopic surgery in the post-operative anesthesia care unit (PACU).
Post-operative nausea and vomiting remains a significant complication following general anesthesia, particularly when volatile anesthetics are used. Previous studies, including a multicenter randomized trial conducted in Australia, have explored alternative treatment modalities for PONV. Chewing gum, a non-pharmacological intervention, has shown promise as a potential alternative or adjunct to conventional antiemetics like ondansetron. This study focuses on the Lebanese female population, aged 18 and above, who have undergone laparoscopic surgery under volatile anesthetic-based general anesthesia. This demographic is chosen based on established risk factors for PONV and may offer unique insights into efficacy within this subgroup.
638 studies on the registry are indexed under Postoperative Nausea and Vomiting; 110 are open to participants now.
This study's planned enrollment of 90 is below the median of 112 across 529 interventional studies indexed under Postoperative Nausea and Vomiting.
Browse Postoperative Nausea and Vomiting studies →Makassed General Hospital is the lead sponsor of 39 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Drug: Ondansetron (Zofran)
Other: chewing gum
Combination Product: Ondansetron + Chewing gum
4 mg IV push
Peppermint sugar free chewing gum
Ondansetron 4 mg IV push Peppermint sugar free chewing gum
Complete cessation of PONV with no recurrence and no rescue medication
Time frame: 2 hours
Patient satisfaction
Time frame: post-operative period ( up to 3 hours)
Quantity of rescue treatment modalities used
Time frame: immediately after PONV start until complete resolution of symptoms
Plan to share: No
This study is active, not recruiting, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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Postoperative Nausea and Vomiting →
Makassed General Hospital