An interventional study of Micro-osteoperforations (MOPs) and Conventional Canine Retraction in Malocclusion, Angle Class I, sponsored by Can Tho University of Medicine and Pharmacy. Completed at 1 site in Vietnam. Open to participants aged 16 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-04.
Sponsored by Can Tho University of Medicine and Pharmacy · Not applicable, Interventional, and Treatment
This single-blinded, split-mouth randomized controlled trial investigates whether micro-osteoperforations (MOPs) can accelerate maxillary canine retraction in orthodontic patients requiring bilateral premolar extraction. The study also evaluates postoperative pain levels using the Visual Analog Scale at 1, 3, and 7 days.
MOPs are a flapless, minimally invasive surgical technique that stimulates bone remodeling and may reduce orthodontic treatment time. In this trial, one side of each patient receives MOPs while the contralateral side serves as control. Canine retraction is performed using miniscrews, power arms, and NiTi coil springs. Outcomes include the rate of canine movement over 16 weeks and pain assessment using VAS.
Exclusion Criteria:
On the experimental side, micro-osteoperforations (MOPs) were performed distal to the maxillary canine under local anesthesia using the Excellerator RT device. Three perforations, each 1.5 mm in diameter and 5 mm deep, were created in the attached gingiva. Canine retraction was then carried out using miniscrew anchorage and NiTi closed-coil springs.
Procedure: Micro-osteoperforations (MOPs)
On the control side, maxillary canine retraction was performed using miniscrew anchorage and NiTi closed-coil springs without any micro-osteoperforations. The mechanics were identical to the experimental side to ensure comparability.
Procedure: Conventional Canine Retraction
Maxillary canine retraction with miniscrew anchorage and NiTi closed-coil springs, without micro-osteoperforations.
Maxillary canine retraction with miniscrew anchorage and NiTi closed-coil springs, without micro-osteoperforations
Rate of Maxillary Canine Retraction
Distance of maxillary canine retraction measured on 3D digital dental models using intraoral scanning.
Time frame: Baseline, 4, 8, 12, and 16 weeks
Pain Level (VAS Score)
atient-reported pain intensity measured using a 10-cm Visual Analog Scale (VAS), with scores ranging from 0 (no pain) to 10 (worst pain imaginable).
Time frame: Day 1, Day 3, Day 7 after intervention
Plan to share: No — Individual participant data (IPD) will not be shared because the study has a small sample size and the data may compromise patient confidentiality.
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This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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Can Tho University of Medicine and Pharmacy