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CompletedNCT07139340Updated Jul 8, 2026

Does the Use of HA Gel Following Third Molar Extraction Decrease the Incidence of Alveolar Osteitis?

An interventional study of HA gel in Alveolar Osteitis, sponsored by Delta University for Science and Technology. Completed at 1 site in Egypt. Open to participants aged 18 Years to 33 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-08.

Sponsored by Delta University for Science and Technology · Not applicable, Interventional, and Prevention

From the registry’s dates

  • Registered 3 years 11 months after the study started (first participant enrolled Aug 2021, registered Aug 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
64
Allocation
Randomized
Ages
18 Years to 33 Years
Sex
All
01

Study summary

The study aimed to investigate the effectiveness of Hyaluronic Acid gel on decreasing the incidence of alveolar osteitis after mandibular third molar extraction.

02

Conditions studied

  • Alveolar Osteitis

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03

In context

Dry Socket

46 studies on the registry are indexed under Dry Socket; 10 are open to participants now.

This study's enrollment of 64 is close to the median of 60 across 41 interventional studies indexed under Dry Socket.

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Lead sponsor

Delta University for Science and Technology is the lead sponsor of 86 studies on the registry; 16 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 33 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Healthy patients (ASA=1)
  • Patients need extraction of mandibular third molar
  • Patients can attend recalls

Exclusion criteria

Exclusion Criteria:

  • Smoking patients
  • Patients taking oral pills
  • Bad oral hygiene
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Contraception

Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.

Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.

05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
64 participants (actual)

Study arms

  • Active comparator
    Study group (HA gel)

    HA gel was placed intrasocket after extraction

    Other: HA gel

  • No intervention
    Control group (No HA gel)

    Nothing was placed intrasocket after extraction

Interventions

  • OtherHA gel

    Hyaluronic Acid gel 0.8% 1 mL

    Also known as: Hyaluronic Acid gel

06

What researchers measure

Primary outcomes

  1. Occurence of Alveolar Osteitis (AO)

    Presence of empty extraction socket without healing clot indicates AO (measured by clinical inspection; Presence of AO=1, Absence of AO=0)

    Time frame: 7 postoperative days

Secondary outcomes

  1. Postoperative pain

    Presence of postoperative pain (measured by Visual Analogue Scale (VAS) from 0 (least pain) to 10 (worst pain))

    Time frame: 7 postoperative days

07

Study locations

1 site
  • Delta university for science and technology
    Gamasa, Dakahlia Governorate 7731168, Egypt
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07139340
Lead sponsor
Delta University for Science and Technology
Collaborators
Mansoura University
Responsible party
Sponsor
First posted
Aug 24, 2025
Start date
Aug 30, 2021
Primary completion
Aug 1, 2025
Completion
Dec 1, 2025
Last update
Jul 8, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2021. You cannot join it, but the record below documents what was studied.

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