An interventional study of sensorimotor proprioceptive stimulation and conventional physical therapy in Carpel Tunnel Syndrome, sponsored by Delta University for Science and Technology. Not yet recruiting at 1 site in Egypt. Open to participants aged 30 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Delta University for Science and Technology · Not applicable, Interventional, and Treatment
This randomized controlled trial will evaluate whether adding sensorimotor proprioceptive stimulation to conventional physiotherapy improves symptoms and hand function in patients with mild-to-moderate carpal tunnel syndrome. The primary outcome is change in the Boston Symptom Severity Scale, while secondary outcomes include functional status, pain, paresthesia, nerve conduction, median-nerve morphology, proprioception, and hand strength.
This randomized controlled trial will investigate whether adding sensorimotor proprioceptive stimulation to conventional physical therapy improves symptoms, sensory function, proprioception, and hand function in adults with mild-to-moderate carpal tunnel syndrome.
Participants will be randomly assigned to either an experimental group receiving sensorimotor proprioceptive stimulation plus conventional physical therapy or a control group receiving conventional physical therapy alone. The intervention will target sensory awareness, wrist and hand joint-position control, median-nerve function, coordination, and functional hand use.
Experimental Intervention
The experimental group will receive a structured program involving:
Wrist and hand joint-position-reproduction exercises.
Visual and nonvisual proprioceptive training.
Controlled wrist, thumb, and finger movements.
Tendon-gliding and median-nerve-gliding exercises.
Graded tactile and sensory stimulation.
Grip, pinch, and fine-motor coordination activities.
Progressive closed-chain or weight-bearing exercises, when tolerated.
Home exercises performed according to a standardized program.
Exercises will progress from simple, visually guided movements to more challenging tasks performed with reduced visual feedback and increased functional demand. The therapist will monitor symptom aggravation, numbness, pain, fatigue, and movement accuracy throughout treatment.
Delta University for Science and Technology is the lead sponsor of 85 studies on the registry; 17 are open to participants now.
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Exclusion Criteria:
Cervical radiculopathy, brachial plexopathy, or another peripheral neuropathy.
Other: sensorimotor proprioceptive stimulation
Other: conventional physical therapy
Participants will receive sensorimotor proprioceptive stimulation combined with conventional physical therapy. The program will include joint-position training, tactile sensory stimulation, wrist and hand coordination exercises, tendon and median-nerve gliding, grip and pinch activities, and progressive functional hand exercises.
Participants will receive conventional physical therapy alone, including education, ergonomic advice, wrist and hand range-of-motion exercises, tendon-gliding exercises, strengthening exercises, and a standardized home-exercise program.
Boston Carpal Tunnel Questionnaire Symptom Severity Scale
The Boston Carpal Tunnel Questionnaire Symptom Severity Scale consists of 11 items assessing pain, numbness, tingling, weakness, nocturnal symptoms, and difficulty grasping objects. Each item is scored from 1 to 5. The total score will be calculated as the mean of the 11 item scores: Mean SSS score = sum of the 11 item scores ÷ 11 The final score ranges from 1 to 5, with higher scores indicating greater symptom severity.
Time frame: baseline
Pain Intensity
Pain intensity will be assessed using a visual analogue scale. Participants will mark their pain intensity on a continuous 10-cm line, where 0 cm represents no pain and 10 cm represents the worst possible pain. The distance from 0 cm to the participant's mark will be recorded.Unit of Measure: Centimeters (cm)
Time frame: baseline
Median sensory nerve-conduction velocity (m/s)
Median sensory nerve-conduction velocity will be measured using standard nerve-conduction studies by stimulating the median nerve at a predefined site and recording the sensory nerve action potential from the selected digit. Conduction velocity will be calculated as the distance between the stimulation and recording sites divided by the relevant conduction time. Unit of Measure: Meters per second (m/s)
Time frame: baseline
Unit of Measure Degrees (°)
Unit of Measure Degrees (°)will be assessed using a joint-position-reproduction test. Participants will reproduce a predefined target wrist position without visual feedback. The absolute angular error will be calculated as the absolute difference between the target angle and the reproduced angle. Errors from the predefined trials will be averaged to obtain one participant-level outcome value. A smaller error indicates better proprioceptive accuracy. Unit of Measure Degrees (°)
Time frame: baseline
Median-Nerve cross sectional area (mm²)
The median nerve will be examined using diagnostic ultrasound. The primary measurement will be the cross-sectional area of the median nerve at the carpal tunnel, usually measured at the tunnel inlet unit of measure Square millimeters (mm²)
Time frame: baseline
Plan to share: No — confidentiality
No publications or documents are linked to this record.
Start is estimated for Oct 2026; primary completion for Jan 2027, 3 months later.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Delta University for Science and Technology