An interventional study of Topical Ozone Therapy and Irrigation with saline in Alveolar Osteitis, sponsored by Menoufia University. Not yet recruiting. Open to participants aged 20 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-08-06.
Sponsored by Menoufia University · Not applicable, Interventional, and Treatment
This clinical study investigates the effectiveness of ozone therapy in comparison to conventional treatment for alveolar osteitis (AO), a common painful complication following tooth extraction. Forty patients diagnosed with dry socket will be randomly divided into two groups. Group A will receive traditional treatment with normal saline irrigation and analgesics, while Group B will be treated using ozonated water, ozonated gel, and analgesics. Both groups will be monitored over a two-week period to evaluate pain levels, healing progression, and other clinical indicators. The study aims to assess the palliative and regenerative benefits of ozone therapy in managing AO, potentially offering an alternative to conventional symptomatic treatments.
Alveolar osteitis (AO), commonly referred to as "dry socket," is a frequent postoperative complication following tooth extraction. It typically presents 1-3 days post-extraction with severe pain due to premature loss or breakdown of the blood clot within the extraction socket. While the exact pathogenesis remains controversial, enhanced fibrinolytic activity, bone trauma, and bacterial contamination are considered primary contributing factors. The incidence is notably higher in mandibular third molars.
Traditional management approaches-such as saline irrigation, antibiotics, and eugenol-based dressings-are often palliative and do not directly target the underlying cause. Ozone therapy, with its antimicrobial, analgesic, and wound-healing properties, has recently emerged as a potential alternative. Ozone, when applied in water or gel forms, is believed to promote clot stability, reduce pain, and enhance soft tissue regeneration.
Aim of the Study:
To assess and compare the palliative (pain-relieving) and regenerative (healing-promoting) effects of ozone therapy versus conventional treatment in patients suffering from alveolar osteitis.
46 studies on the registry are indexed under Dry Socket; 10 are open to participants now.
This study's planned enrollment of 40 is below the median of 60 across 41 interventional studies indexed under Dry Socket.
Browse Dry Socket studies →Menoufia University is the lead sponsor of 199 studies on the registry; 54 are open to participants now.
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Age: 18-60 years.
Patients undergoing simple (non-surgical) extractions.
Medically healthy individuals.
Exclusion Criteria:
Patients already treated for AO.
Presence of systemic diseases affecting healing.
Severe infections or facial swelling.
Incomplete follow-up.
to ozone therapy: G6PD deficiency, hyperthyroidism, malignant hypertension, recent myocardial infarction.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Socket debridement and irrigation with normal saline. Pain management using Diclofenac potassium (50 mg TID). Follow-up at day 2, 3, 7, 10, and 14. Home care: saline mouth rinse.
Other: Irrigation with saline
Socket debridement and irrigation with ozonated water. Application of ozonated gel into the socket using syringe with fine-tip applicator. Pain management using Diclofenac potassium (50 mg TID). Patients instructed to use ozonated water and gel at home daily. Follow-up at day 2, 3, 7, 10, and 14.
Other: Topical Ozone Therapy
The intervention involves local application of ozone in two forms: Ozonated Water - used for irrigation of the extraction socket. Ozonated Gel - applied topically inside the socket to promote healing and reduce pain. Both are used after socket debridement and bleeding provocation, followed by standard analgesic administration (Diclofenac potassium).
The intervention involves irrigation with saline
Pain Reduction
Patient-reported pain scale, categorized as: Severe Moderate Mild No pain
Time frame: Pain intensity will be recorded at: Day 2 Day 3 Day 7 Day 10 Day 14
No study locations are listed for this record.
Plan to share: No — Up on request from the corresponding author
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.
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