An interventional study of Olfactory stimulation in Disorders of Consciousness Due to Severe Brain Injury, sponsored by Centre Hospitalier St Anne. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-17.
Sponsored by Centre Hospitalier St Anne · Not applicable, Interventional, and Diagnostic
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Among 72 studies in Brain Injuries with a site in France — 19 open to participants now, 20 under way, none of them phase 3. Brain Injuries · France.
Among the 72 studies in Brain Injuries with a site in France, this one is the 13th largest by planned enrollment of the 36 interventional ones that give a count, is one of 4 that started in 2024, is one of 26 with no phase, reaches primary completion later than 11 of the 19 other live ones, and was the 67th registered.
947 studies on the registry are indexed under Brain Injuries; 236 are open to participants now.
Browse Brain Injuries studies →19 of the 72 studies in Brain Injuries with a site in France are open now. Recruiting first, the newest first:
Centre Hospitalier Universitaire de Nīmes · Sites in France
Ages 18+
Hospices Civils de Lyon · Sites in France
Ages 17+
Centre Hospitalier Universitaire de Saint Etienne · Sites in France
Ages 18+
Assistance Publique - Hôpitaux de Paris · Sites in France
Ages 18+
Hospices Civils de Lyon · Sites in France
Ages 18+
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 152 Brain Injuries studies recruiting now, 75 (49%) set no upper age limit and 55 (36%) stop at 75 or younger; 39 take children under 18; 23 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
72 studies; the count open now beside each. This study's row is marked.
First in 2002; this study’s year is marked. 4 started in 2024.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 96 is above the median of 41 across 613 interventional studies indexed under Brain Injuries.
Median enrollment 46 across the 36 interventional studies, 124 across the 36 observational. Of the 44 that completed or were terminated, 2 (5%) have results posted.
This tab as a report to print or save as PDF → With an account.
2 of 72 have an industry lead sponsor. The 10 most frequent:
Centre Hospitalier St Anne is the lead sponsor of 101 studies on the registry; 55 are open to participants now.
Centre Hospitalier St Anne has 2 studies filed under Brain Injuries — fewer than ten, so there is no comparison to draw.
4 of the studies in Brain Injuries with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT04080440University Hospital, Clermont-FerrandBrain-injured Patients Extubation Readiness Study | 2027-02-13 |
| NCT07085403Hopitaux de Saint-MauriceLet's CO-OPerate! Together we Are Stronger | 2027-05-01 |
| NCT07127224Centre Hospitalier St AnneConsciousness Prognosis Evaluation Using Olfactory Stimulations in Comatose Patients) | 2027-05-05 |
| NCT07450404Central Hospital, Nancy, FrancePK/PD Target Attainment of Ceftriaxone for the Prevention of Early Ventilator-associated Pneumonia in Neurologically Injured Patients | 2027-09-01 |
Add all 4 to your calendar (.ics) → With an account.
Among the 72 studies in Brain Injuries with a site in France, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The goal of this observational study is to determine whether the clinical response to olfactory stimulation (known as the "sniff" response) can help predict 3-month neurological outcomes in ICU patients with persistent disorders of consciousness after sedation withdrawal, regardless of the reason for admission or the initial severity.
The main questions this study aims to answer are:
Participants will receive additional olfactory stimuli as part of the neurophysiological evaluation for prognostic purposes and be followed up at 3 months for clinical, neurological, and functional evaluation
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Adult ICU patients with disorders of consciousness will undergo non-invasive neurophysiological assessments including olfactory, auditory, and somatosensory stimulations. Olfactory stimuli are added for prognostic evaluation. Clinical and neurological follow-up will be done at 3 months.
Diagnostic Test: Olfactory stimulation
Olfactory stimulation ("sniff" test) combined with auditory and somatosensory stimulations during bedside neurophysiological assessments to evaluate neurological prognosis in ICU patients.
Glasgow Outcome Scale-Extended (GOS-E) score at 3 months
Time frame: 3 months after inclusion
Plan to share: Undecided
No publications or documents are linked to this record.
Started Feb 2024 (actual). Primary completion is estimated for May 2027, 39 months after the start.
Of 284 non-industry interventional studies with no phase under Brain Injuries, half reached primary completion within 26 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 50. This study's planned 39 months is above that.
Counting every sponsor, half of 297 studies reached it within 24 months; a quarter within 12 and three quarters within 48.
How these figures are worked out, and which studies are left out of them.
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