A Phase 3 interventional study of Toothpaste Tablet and Conventional Toothpaste in Gingival Inflammation and Dental Caries, sponsored by Loma Linda University. Not yet recruiting at 2 sites in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-10.
Sponsored by Loma Linda University · Phase 3, Interventional, and Prevention
Objectives: To evaluate the effectiveness of toothpaste tablets when compared to conventional dentifrices in removing plaque.
Methods: 50 participants are randomized into two groups: Denttabs toothpaste tablets (T) and Colgate's Cavity Protection toothpaste (P). Both groups utilize their assigned dentifrice for 6 weeks. A pre and post-assessment measures the Gingival Index (GI) and Plaque Index (PI) and Decayed, Missing and Filled Teeth (DMFT). A questionnaire on the use of the product is distributed at the end of the study.
631 studies on the registry are indexed under Gingivitis; 107 are open to participants now.
This study's planned enrollment of 50 is below the median of 66 across 507 interventional studies indexed under Gingivitis.
Browse Gingivitis studies →Loma Linda University is the lead sponsor of 306 studies on the registry; 46 are open to participants now.
Of its 29 completed or terminated interventional studies of FDA-regulated products, 23 (79%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
1. Subjects under the age of 18.
Subjects are instructed to use one toothpaste tablet at each brushing. Brushing is recommended twice daily for two minutes.
Drug: Toothpaste Tablet
Subjects are instructed to use the toothpaste at each brushing. Brushing is recommended twice daily for two minutes.
Drug: Conventional Toothpaste
Denttabs toothpaste tablets
Also known as: Denttabs Toothpaste Tablets
Colgate Cavity Protection toothpaste
Also known as: Colgate Cavity Protection
Plaque Index Score at Baseline
The quantity of plaque build-up is measured visually using the Quigley-Hein Plaque Index. The Plaque index can range from 0 to 5, with higher numbers indicating more plaque build-up.
Time frame: Change between baseline at visit 1 and visit 2, six weeks post baseline
Gingival Index Score at Baseline
The severity of gingival inflammation is measured visually using the Loe-Silness Gingival Index. Gingival index can range from 0 to 3, with higher numbers indicating more gingival inflammation.
Time frame: Change between baseline at visit 1 and visit 2, six weeks post baseline
DMFT Score at Baseline
Caries experiences is measured visually using the DMFT index. DMFT score can range from 0 to 28, with higher numbers indicating higher caries experiences.
Time frame: Change between baseline at visit 1 and visit 2, six weeks post baseline
Subject Perception of Product Use
The perception on the product usage is measured using a survey containing questions on feel, texture, flavor, ease of use, eco-friendliness, cost and overall satisfaction. Response is on a 4 point Likert scale ranging from strongly agree (1) to strongly disagree (4).
Time frame: Visit 2 six weeks post study enrollment
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Studies of the drug tested here: Toothpaste