Drug
Fluorophosphate clinical trials
How each study uses fluorophosphate is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Approvals
The first approval found in each region, with its record
- United States
- 6 Aug 1986 · EXTRA-STRENGTH AIM · NDA 019518 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Name
- Colgate Cavity protection toothpaste
- 2
Studies by the year they started
3 studies that test it; most in 2020 (1)
| Year | Studies |
|---|---|
| 2020 | 1 |
| 2023 | 1 |
| 2025 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 3 · Other 0
Colgate Palmolive (1) · Procter and Gamble (1) · Solventum US LLC (1)
Often tested with
Tested in the same studies.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Tested against it · 3 phase 3 studies under way
Fluorophosphate is the comparator. A study of two new drugs counts under both.
- 1Toothpaste · Loma Linda University · next primary completion Dec 2026
Studies
Open first, then newest update. How each study uses fluorophosphate is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 3
- To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Protection Toothpaste in the Reduction of Dentinal Hypersensitivity.CompletedPhase 3Colgate PalmoliveNCT07149376Written as Colgate Cavity protection toothpaste
- 3M Oral Rinse Incidence and Patient Acceptance of Sloughing When Used With Sodium Lauryl Sulfate (SLS) ToothpastesTerminatedNot applicableSolventum US LLCNCT04601103Written as High SLS toothpaste
- Evaluation of the Anticaries Efficacy of Dentifrice Formulations Using an In-situ ModelCompletedNot applicableProcter and GambleNCT06140758Written as Oral-B 1450 ppm Fluoride (1.16% sodium monofluorophosphate) Dentifrice
Given beside what is tested · 3 — fluorophosphate is usual care or a partner of the new treatment
- A Two-Week Study of an Anticavity Low pH MouthwashCompletedPhase 4Johnson & Johnson Consumer Inc. (J&JCI)NCT06010758Written as Colgate Cavity Protection Toothpaste
- A Study to Investigate Salivary Flow and Potential of Hydrogen (pH) Following Use of Essential-Oil Containing MouthwashesCompletedPhase 4Johnson & Johnson Consumer Inc. (J&JCI)NCT06136455Written as Colgate Cavity Protection Toothpaste
- A Study of Virtually Supervised Mouthwash and Interdental BrushesCompletedPhase 4Johnson & Johnson Consumer Inc. (J&JCI)NCT05756673Written as Colgate Cavity Protection Toothpaste
As the comparator · 31 — what is tested is compared with fluorophosphate
- Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum ProblemsRecruitingPhase 3Colgate PalmoliveNCT07842991Written as Colgate Cavity Protection Toothpaste
- Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries ExperiencesNot yet recruitingPhase 3Loma Linda UniversityNCT07124533Written as Conventional Toothpaste
- Efficacy of a Toothpaste in Reducing Plaque, Gingivitis, and Gingival BleedingNot yet recruitingPhase 3Colgate PalmoliveNCT07499115Written as Colgate Cavity Protection Toothpaste
- Clinical Investigation of Oral Malodor for Max Fresh Toothpaste Containing Zinc Citrate Versus a Commercially Available Regular Fluoride ToothpasteCompletedPhase 3Colgate PalmoliveNCT07398378Written as Colgate Cavity Protection Toothpaste
- Clinical Study to Investigate the Ability of a Stannous Fluoride Toothpaste to Protect From Dentine HypersensitivityCompletedNot applicableHALEONNCT06733285Written as Colgate Cavity Protection
- Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the MouthCompletedPhase 3Colgate PalmoliveNCT07458464Written as 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste
- A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque AccumulationCompletedNot applicableHALEONNCT07255040Written as Colgate Cavity Protection
- Dentin Hypersensitivity Reduction Efficacy ClinicalCompletedPhase 3Colgate PalmoliveNCT07738198Written as 0.76% sodium monofluorophosphate
- Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.CompletedPhase 3Colgate PalmoliveNCT07398846Written as 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste
- Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control.CompletedPhase 2Procter and GambleNCT06892834Written as Sodium monofluorophosphate dentifrice
- Efficacy of Manual Toothbrushes in Removing Tooth StainsCompletedPhase 3Colgate PalmoliveNCT06486974Written as Na MFP
- The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis.CompletedPhase 3Colgate PalmoliveNCT06427499Written as Colgate Cavity Protection Toothpaste
- A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival HealthCompletedNot applicableHALEONNCT06602466Written as Colgate Cavity Protection Toothpaste
- A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival HealthCompletedNot applicableHALEONNCT07169188Written as Colgate Cavity Protection Toothpaste
- Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period.CompletedPhase 2/3Colgate PalmoliveNCT07223060Written as 0.76% sodium monofluorophosphate
- Oothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal HypersensitivityCompletedPhase 3Colgate PalmoliveNCT07257042Written as Colgate Cavity Protection Toothpaste
- A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New ToothpasteCompletedPhase 3Colgate PalmoliveNCT07223073Written as 0.76% sodium monofluorophosphate
- Assessing Gingivitis and Plaque From a Marketed ToothpasteActive, not recruitingPhase 4Procter and GambleNCT07158112Written as Sodium monofluorophosphate dentifrice
- Evaluating Gingivitis and Systemic BiomarkersActive, not recruitingPhase 1Procter and GambleNCT06962956Written as 0.76% Sodium Monofluorophosphate Dentifrice
- Arginine Plaque Metabolism Pilot Clinical StudyCompletedPhase 3Colgate PalmoliveNCT06954779Written as Colgate Cavity Protection
Showing 20 of 31.
Codes
What other systems call fluorophosphate · ClinicalTrials.gg INT002565
- MeSH (NLM) C012980fluorophosphateConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) 8L3LWO8VZ3CALCIUM FLUOROPHOSPHATEConfirmed NLM, Wikidata
- RxNorm 2463340One source FDA
- Wikidata Q2237310calcium fluorophosphateConfirmed NLM, Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C012980 | fluorophosphate | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | 8L3LWO8VZ3 | CALCIUM FLUOROPHOSPHATE | Confirmed NLM, Wikidata |
| RxNorm | 2463340 | — | One source FDA |
| Wikidata | Q2237310 | calcium fluorophosphate | Confirmed NLM, Wikidata |
Also registered as ammonium monofluorophosphate (UNII FS46648QNC) and sodium monofluorophosphate (UNII C810JCZ56Q · RxNorm 56501).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.