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CompletedNCT07095777Updated Jul 31, 2025

Study on the Recovery of Visual Perceptual Function Dysfunction in Patients With Diabetes

An interventional study of visual perceptual learning in Diabetic Retinopathy (DR) and Visual Perception, sponsored by The First Affiliated Hospital of Anhui Medical University. Completed at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-07-31.

Sponsored by The First Affiliated Hospital of Anhui Medical University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 2 years 4 months after the study started (first participant enrolled Mar 2023, registered Jul 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
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Study summary

Investigators aim to investigate the effectiveness of visual perceptual learning on visual perceptual function in participants with diabetic retinopathy and to provide novel therapeutic insights for visual functional rehabilitation in diabetic retinopathy.

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Conditions studied

  • Diabetic Retinopathy (DR)
  • Visual Perception

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In context

Diabetic Retinopathy

773 studies on the registry are indexed under Diabetic Retinopathy; 139 are open to participants now.

This study's enrollment of 36 is below the median of 78 across 480 interventional studies indexed under Diabetic Retinopathy.

Browse Diabetic Retinopathy studies →

Lead sponsor

The First Affiliated Hospital of Anhui Medical University is the lead sponsor of 42 studies on the registry; 16 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • moderate to severe non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy(PDR) prior to treatment(17)
  • prior pan retinal laser photocoagulation (PRP) at least 4 weeks before enrollment or vitreoretinal surgery at least 8 weeks before enrollment
  • stable clinical condition
  • best-corrected visual acuity (BCVA) > 1.0 logMAR (equivalent to a Snellen visual acuity of \< 20/200)
  • clear refractive media
  • age ≤ 65 years
  • ability to comprehend the examination and training procedures

Exclusion criteria

Exclusion Criteria:

  • significant refractive media opacity
  • psychiatric disorders, chronic alcoholism and traumatic brain injury
  • new-onset vitreous hemorrhage, myopia, strabismus, amblyopia, glaucoma and macular diseases.
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
36 participants (actual)

Study arms

  • Experimental
    visual perceptual learning group

    Procedure: visual perceptual learning

  • No intervention
    control group

Interventions

  • Procedurevisual perceptual learning

    Participants in the VPL group performed 40 minutes of daily monocular training at home for three months, with follow-up evaluations conducted at 1 month and 3 months after training initiation.

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What researchers measure

Primary outcomes

  1. contrast sensitivity

    The contrast sensitivity measurements include grating acuity, first-order motion stimulus perception sensitivity, second-order stationary stimulus perception sensitivity and second-order motion stimulus perception sensitivity, which represent the reciprocal of the contrast threshold.

    Time frame: From enrollment to the end of treatment at 12 weeks

Secondary outcomes

  1. The Low Vision Quality of Life Questionnaire

    This instrument has demonstrated high reliability and validity, and is sensitive to changes in visual function among individuals with vision loss. The minimum value is 25 and the maximum value is 125. Higher scores indicate better quality of life.

    Time frame: From enrollment to the end of treatment at 12 weeks

Other outcomes

  1. The Hospital Anxiety and Depression Scale

    The scale aims to measure anxiety and depression levels in hospital patients with high reliability and validity. The Hospital Anxiety and Depression Scale (HADS) provides separate scores for anxiety (HADS-A) and depression (HADS-D), each ranging from 0 to 21. A lower score indicates a lesser degree of anxiety and depression.

    Time frame: From enrollment to the end of treatment at 12 weeks

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Study locations

1 site
  • The First Affiliated Hospital of Anhui Medical University
    Hefei, Anhui, China
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References and documents

Study documents

  • Protocol and statistical analysis plan · Aug 10, 2024

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No — Individual participant data will not be shared due to ethical and privacy considerations. Participants did not consent to data sharing in the informed consent form.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 31, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07095777
Lead sponsor
The First Affiliated Hospital of Anhui Medical University
Responsible party
Lixia Feng (Chief physician, Doctoral supervisor, The First Affiliated Hospital of Anhui Medical University) — Principal investigator
First posted
Jul 31, 2025
Start date
Mar 1, 2023
Primary completion
Jul 31, 2024
Completion
Aug 9, 2024
Last update
Jul 31, 2025

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.

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