An observational study in Arteriovenous Malformation of Central Nervous System, Aneurysm, Ruptured and Aneurysmatic Subarachnoid Haemorrhage, sponsored by The First Affiliated Hospital with Nanjing Medical University. Recruiting at 2 sites in China. Per ClinicalTrials.gov, last updated 2025-07-03.
Sponsored by The First Affiliated Hospital with Nanjing Medical University · Observational
AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.
29 studies on the registry are indexed under Aneurysm, Ruptured; 7 are open to participants now.
This study's planned enrollment of 200 is close to the median of 183 across 12 observational studies indexed under Aneurysm, Ruptured.
Browse Aneurysm, Ruptured studies →The First Affiliated Hospital with Nanjing Medical University is the lead sponsor of 568 studies on the registry; 317 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with posterior circulation malformations combined with ruptured or unruptured flow-related aneurysms will be included. Morphological data such as aneurysm size, location, parent artery, feeding arteries, draining vein count, malformation size, malformation location, and the ratio of malformation/aneurysm volume will be analyzed. These factors will be examined alongside medical histories of hypertension, diabetes, and coronary artery disease to investigate the risk factors for ruptured flow-related aneurysms.
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Exclusion Criteria:
characteristics of flow-related aneurysm
size ratio(aneurysm depth (mm)/parent artery diameter (mm))
Time frame: From enrollment to the end of treatment at 8 weeks
demographic information of pAVM-rFA
gender
Time frame: From enrollment to the end of treatment at 8 weeks
demographic information
age when be hospitalized
Time frame: From enrollment to the end of treatment at 8 weeks
characteristics of flow-related aneurysm
aspect ratio (aneurysm depth (mm)/aneurysm neck (mm))
Time frame: From enrollment to the end of treatment at 8 weeks
characteristic of avm
avm location
Time frame: From enrollment to the end of treatment at 8 weeks
characteristic of avm
Spetzler-Martin grade of avm
Time frame: From enrollment to the end of treatment at 8 weeks
Not enrolling at this site.
Plan to share: Undecided
Started Jun 2025 (actual). Primary completion is estimated for Aug 2025, 2 months after the start.
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The First Affiliated Hospital with Nanjing Medical University →