Arteriovenous Malformations clinical trials
The registry lists 92 studies for Arteriovenous Malformations across more than 10 countries. 29 are recruiting or about to start. 49 of them are mainly about Arteriovenous Malformations (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Arteriovenous Fistula: 367 studies, 83 open.
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Who runs them
Beijing Tiantan Hospital (8) · Fondation Ophtalmologique Adolphe de Rothschild (4) · University of California, San Francisco (3) · Kaneka Corporation (2) · Hospices Civils de Lyon (2) · University of Arkansas (2) · University Health Network, Toronto (2) · Assiut University (2)
What is being tested here
Drugs under test in Arteriovenous Malformations studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Everolimus | 1 | 0 | 1 |
| Sirolimus | 1 | 0 | 1 |
| Alpelisib | 1 | 0 | 1 |
| Mirdametinib | 1 | 0 | 1 |
| Engasertib | 0 | 0 | 1 |
| Cobimetinib | 0 | 0 | 1 |
| Bevacizumab | 0 | 0 | 1 |
| Minocycline | 0 | 0 | 1 |
| Doxycycline | 0 | 0 | 1 |
| Thalidomide | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Nov 2026Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable Coils · Medtronic Endovascular
- Jan 2027Assess Safety and Efficacy of VAD044 in HHT Patients · Vaderis Therapeutics AG
- Jan 2027A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations · Murdoch Childrens Research Institute
- Feb 2027Genetics of Central Nervous System Arteriovenous Malformations (GENE-MAV) · Fondation Ophtalmologique Adolphe de Rothschild
- Feb 2027Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study · Hospices Civils de Lyon
- May 2027Evaluation of Clinical Outcomes of Unruptured bAVMs Treated With Medical Management Alone Based on Multimodal CT · Beijing Tiantan Hospital
- Jun 2027Neurosurgical Outcome Network · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- Sep 2027Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations · Centre Hospitalier Universitaire, Amiens
- Nov 2027Clinical Study on Emergency Treatment of Cerebral Arteriovenous Malformation Bleeding · Beijing Tiantan Hospital
Who these studies take
Of the 19 Arteriovenous Malformations studies recruiting now, 13 (68%) set no upper age limit and 3 (16%) stop at 75 or younger. 8 (42%) take children under 18. 1 (5%) are for women only and 0 (0%) for men only; 2 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 8 (42%) | 8 (42%) |
| 18 | 19 (100%) | 18 (95%) |
| 30 | 19 (100%) | 18 (95%) |
| 40 | 19 (100%) | 18 (95%) |
| 50 | 18 (95%) | 18 (95%) |
| 65 | 17 (89%) | 17 (89%) |
| 75 | 16 (84%) | 16 (84%) |
| 85 | 14 (74%) | 14 (74%) |
Across all 92 studies, recruiting or not: 20% stop at 75 or younger and 11% at 65; 43% take children; 4% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Arteriovenous Malformations studies take
Of 15 interventional studies with no phase under Arteriovenous Malformations, half reached primary completion within 33 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 33 mo17–77 · 15 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered2
- Fetal Embolization for Severe Vein of Galen Malformation - A Feasibility and Safety TrialNov 10, 2026NCT07927725
- Twenty-five Years of Advanced RadioTherapy at San Raffaele HospitalOct 26, 2026NCT07894900
Studies
Recruiting first, then most recently updated. Showing 50 of 92. Browse all 92 → or search them.
- Fetal Embolization for Severe Vein of Galen Malformation - A Feasibility and Safety TrialNot yet recruitingNCT07927725Not applicable1 country
- Genetics of Central Nervous System Arteriovenous Malformations (GENE-MAV)RecruitingNCT047729631 country
- Harmony-HHT: ATV-1601 in Participants With Hereditary Hemorrhagic Telangiectasia (HHT)RecruitingNCT07601425Phase 1/22 countries
- Twenty-five Years of Advanced RadioTherapy at San Raffaele HospitalNot yet recruitingNCT078949001 country
- Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable CoilsEnrolling by invitationNCT076398531 country
- Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 StudyRecruitingNCT041946191 country
- Rapid Evacuation and Access of Cerebral Hemorrhage RegistryRecruitingNCT076516311 country
- Comprehensive HHT Outcomes Registry of the United States (CHORUS)RecruitingNCT062592921 country
- Exploratory Study of Cerebral Perfusion and Metabolic Alterations and Neurocognitive Disorders in Patients With Unruptured Arteriovenous Malformations Before and After Surgical TreatmentRecruitingNCT07569887Not applicable1 country
- Post-Market Clinical Follow-up Study of i-ED Coil and EDG v4 for Arteriovenous MalformationNot yet recruitingNCT07687472Not applicable
- Shh Signaling in Brain AVMs: Novel Player & Therapeutic TargetNot yet recruitingNCT076767211 country
- Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous MalformationsRecruitingNCT02042326Phase 22 countries
- A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular MalformationsRecruitingNCT05983159Phase 21 country
- Language Function Reorganization in Patients With Arteriovenous MalformationsNot yet recruitingNCT075375041 country
- Neurosurgical Outcome NetworkRecruitingNCT067240291 country
- A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular AnomaliesNot yet recruitingNCT07477548Phase 2
- Microwave Ablation for Treatment of Vascular Malformations: Efficacy and SafetyNot yet recruitingNCT07404670Not applicable
- Long Term Follow-up After Embolization of Brain Arteriovenous MalformationsRecruitingNCT028790711 country
- The Clinical Application of Peripheral Embolization Coil Systems in Arteriovenous Embolization Within the Peripheral VasculatureNot yet recruitingNCT07156409Not applicable
- Clinical Study on Emergency Treatment of Cerebral Arteriovenous Malformation BleedingRecruitingNCT071186311 country
- The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVMRecruitingNCT070503811 country
- Diagnostic Imaging of Vascular Malformations Using MSOT and ULMNot yet recruitingNCT069942601 country
- An Exploratory Study to Evaluate the Efficacy and Safety of FCN-159 in Patients With Brain Arteriovenous MalformationsRecruitingNCT06913725Phase 21 country
- Treatment of Brain AVMs (TOBAS) StudyRecruitingNCT02098252Not applicable6 countries
- Brain Imaging After Non-traumatic Intracranial Hemorrhage (SAVEBRAINPWI)RecruitingNCT052769341 country
- Evaluation of Clinical Outcomes of Unruptured bAVMs Treated With Medical Management Alone Based on Multimodal CTRecruitingNCT054491061 country
- Genetic, Metabolic, and Growth Factor Repository for Cerebrovascular DisordersRecruitingNCT029101801 country
- Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland ChinaRecruitingNCT045725681 country
- Proton Radiotherapy for Primary Central Nervous System Tumours in AdultsRecruitingNCT02797366Phase 21 country
- Efficacy & Safety of LOBO™ Vascular Occlusion Device for Embolization of Pulmonary Arteriovenous MalformationsActive, not recruitingNCT06735976Not applicable1 country
- Intraoperative Laser Speckle Contrast Imaging of Cerebral Blood FlowSuspendedNCT048657181 country
- Pilot Study on Trametinib for Surgical Unruptured AVMsWithdrawnNCT06098872Phase 21 country
- CHORUS - Comprehensive HHT Outcomes Registry of the United States (Formerly OUR HHT Registry)Active, not recruitingNCT041508221 country
- A Trial of TER-1754 in Patients With Hereditary Hemorrhagic TelangiectasiaWithdrawnNCT07255846Phase 11 country
- Assess Safety and Efficacy of VAD044 in HHT PatientsActive, not recruitingNCT05406362Phase 1/26 countries
- Interest of New MRI Sequences After Embolization of Brain Arteriovenous MalformationsTerminatedNCT028968811 country
- A Study to Evaluate How Safe and Effective is the Mixture of Lipiodol® Ultra Fluid and Glue When Used for Embolization ProceduresCompletedNCT02625389Phase 41 country
- Cobimetinib In Extracranial Arteriovenous Malformations (COBI-AVM Study)CompletedNCT05125471Phase 21 country
- Diagnostic Value of Ultra-low Dose Thoracic Scanner for the Pulmonary Arteriovenous Malformation Detection in HHT PatientCompletedNCT04108052Not applicable1 country
- An Observational Study of Radial Access Embolization Procedures Using HydroPearl MicrospheresCompletedNCT042722161 country
- Transvenous Approach for the Treatment of Cerebral Arteriovenous MalformationsCompletedNCT03691870Not applicable2 countries
- Exacerbation of Erythema Following PDT in Patients With Probable Capillary Malformation-Arteriovenous Malformation Syndrome: Retrospective Analysis of Ultrasound and Clinical Characteristics.CompletedNCT069855631 country
- Functional Navigation in Surgery of Cerebral Tumors and Vascular MalformationsSuspendedNCT05484219Not applicable1 country
- SelfWrap-Assisted Arteriovenous FistulasActive, not recruitingNCT05418816Not applicable1 country
- Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations Using Magnetic Resonance ImagingCompletedNCT039958231 country
- Treating Arteriovenous Malformation With Stereotactic Radiosurgery Using CT Angiography for Treatment PlanningCompletedNCT03559556Early Phase 11 country
- Report of Ten Cases of Venous Aneurysm in ExtremitiesCompletedNCT064375611 country
- Study Comparing Onyx and TRUFILL in Brain Arteriovenous Malformations (AVMs)CompletedNCT00857662Phase 21 country
- Patient Skin Dose in Interventional RadiologyCompletedNCT042461251 country
- Outcome and Prognostic Factors of Surgical Management of Scalp AVMs.Status unknownNCT05341336Not applicable1 country