CClinicalTrials.gg
CompletedNCT07022665Updated Jun 15, 2025

Influence of Hospital Volume on Mortality and Short-term Postoperative Outcomes in Uncomplex General Surgery in Switzerland

An observational study in Cholecystolithiasis, Cholecystitis and Inguinal Hernia, sponsored by Cantonal Hospital of St. Gallen. Completed at 1 site in Switzerland. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2025-06-15.

Sponsored by Cantonal Hospital of St. Gallen · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
399,701
Ages
20 Years and older
Sex
All
01

Study summary

The effect of centralisation measures on the operative outcomes after any type of surgery in Switzerland has not been highlighted yet. This study aims to investigate the influence of the annual case-specific hospital volume on uncomplex general surgery. The four operations investigated are appendectomy, cholecystectomy, umbilical hernia repair, and inguinal/femoral hernia repair.

02

Conditions studied

  • Cholecystolithiasis
  • Cholecystitis
  • Inguinal Hernia
  • Femoral Hernia
  • Umbilical Hernia
  • Appendicitis
03

Who can participate

Ages eligible
20 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

All patients with with appendicectomy for appendicitis, cholecystectomy for cholecystolithiasis and/or cholecystitis , umbilical hernia repair, or inguinal and/or femoral hernia repair operated in Switzerland between 2013 and 2022.

Inclusion criteria

  • All patients with appendicectomy for appendicitis, cholecystectomy for cholecystolithiasis and/or cholecystitis , umbilical hernia repair, or inguinal and/or femoral hernia repair

Exclusion criteria

Exclusion Criteria:

  • incomplete case documentation
  • age under 20 years
  • other hospitals than general or surgical hospitals
  • no index operation
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
399,701 participants (actual)
Target follow-up
90 Days
Patient registry
Yes

Groups and cohorts

  • Appendicectomy

    Procedure: Appendicectomy

  • Cholecystectomy

    Procedure: Cholecystectomy

  • Umbilical hernia repair

    Procedure: Umbilical hernia repair

  • Inguinal and/or femoral hernia repair

    Procedure: Inguinal and/or femoral hernia repair

Interventions

  • ProcedureAppendicectomy

    Appendicectomy for appendicitis

  • ProcedureCholecystectomy

    Cholecystectomy for cholecystolithiasis and/or cholecystitis

  • ProcedureUmbilical hernia repair

    Any kind of umbilical hernia repair

  • ProcedureInguinal and/or femoral hernia repair

    Any kind of inguinal and/or femoral hernia repair

05

What researchers measure

Primary outcomes

  1. Mortality

    The association between the hospital volume and the postoperative mortality Mortality Yes or No Hospital volume as marginal effect Association with GAM logistic regression

    Time frame: Periprocedural

Secondary outcomes

  1. Reoperation

    The association between the hospital volume and the reoperation rate Reoperation Yes or No Hospital volume as marginal effect Association with GAM logistic regression

    Time frame: Periprocedural

  2. Length of hospital stay

    The association between the hospital volume and the length of hospital stay Length of hospital stay in days Hospital volume as marginal effect Association with quantile regression

    Time frame: Periprocedural

  3. Sociodemographic trends

    Time frame: 2013 - 2022

06

Study locations

1 site
  • HOCH Health Ostschweiz, Kantonsspital St.Gallen
    St.Gallen, 9000, Switzerland
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07022665
Lead sponsor
Cantonal Hospital of St. Gallen
Responsible party
Yanic Ammann (Principal Investigator, Cantonal Hospital of St. Gallen) — Principal investigator
First posted
Jun 15, 2025
Start date
Jan 1, 2013
Primary completion
Dec 31, 2022
Completion
Mar 1, 2023
Last update
Jun 15, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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