An interventional study of Transcutaneous Electrical Nerve Stimulation Device and Strength exercises for lower limb in Hamstring Shortness, Patellofemoral Pain Syndrome and Hamstring Flexibility, sponsored by Cairo University. Not yet recruiting at 1 site in Egypt. Open to participants aged 18 Years to 37 Years. Per ClinicalTrials.gov, last updated 2025-06-15.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
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Among 30 studies in Patellofemoral Pain Syndrome by Cairo University — 12 open to participants now, 13 under way, none of them phase 3. Patellofemoral Pain Syndrome · Cairo University.
Among the 30 studies in Patellofemoral Pain Syndrome by Cairo University, this one is the 5th largest by planned enrollment of the 22 interventional ones that give a count, is one of 3 that started in 2025, is one of 22 with no phase, reaches primary completion later than 2 of the 12 other live ones, and was the 18th registered.
297 studies on the registry are indexed under Patellofemoral Pain Syndrome; 74 are open to participants now.
Browse Patellofemoral Pain Syndrome studies →12 of the 30 studies in Patellofemoral Pain Syndrome by Cairo University are open now, in 3 countries. Recruiting first, the newest first:
Cairo University · Sites in Lebanon
Ages 18–50
Cairo University · Sites in Egypt
Ages 18–30
Cairo University · Sites in Egypt
Ages 18–35
Cairo University · Sites in Egypt
Ages 18–35
Cairo University · Sites in Egypt
Ages 18–35
By country, each count listing its studies:
Of the 45 Patellofemoral Pain Syndrome studies recruiting now, 3 (7%) set no upper age limit and 41 (91%) stop at 75 or younger; 7 take children under 18; 13 take healthy volunteers.
This study: 18 Years to 37 Years · all sexes · no healthy volunteers.
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30 studies; the count open now beside each. This study's row is marked.
First in 2018; this study’s year is marked. 3 started in 2025.
This study's planned enrollment of 60 is above the median of 45 across 244 interventional studies indexed under Patellofemoral Pain Syndrome.
Median enrollment 58 across the 22 interventional studies, 53 across the 8 observational. Of the 12 that completed or were terminated, 0 (0%) have results posted.
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Cairo University is the lead sponsor of 4,951 studies on the registry; 1,463 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
3 of the studies in Patellofemoral Pain Syndrome by Cairo University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07642011Cairo UniversityRelationship Between Knee Pain And Proprioception During Single Leg Squat In Patellofemoral Pain Syndrome | 2026-11-20 |
| NCT07664566Cairo UniversityCore Stability Exercises Versus Proprioceptive Training on Pain and Function in Patients With Patellofemoral Pain Syndrome | 2027-03-20 |
| NCT07806929Cairo UniversityComparison Between Foot Segment Mulligan Mobilization and Ilium Mulligan Mobilization in Treatment Patellofemoral Pain Patients With Flatfeet: a Randomized Controlled Comparative Study | 2027-11-01 |
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Among the 30 studies in Patellofemoral Pain Syndrome by Cairo University, from their registry updates:
Nothing recorded among them since 2026-09-25.
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This randomized, Single-blind, parallel-group trial will compare the effects of three hamstring stretching interventions-general hamstring Muscle Energy Technique (MET), medial hamstring MET, and lateral hamstring MET-each combined with standardized TENS and progressive hip/knee strengthening, on hamstring flexibility (knee-extension ROM), anterior knee pain (Arabic Kujala score), pain intensity visual analogue scale (VAS), and lower-limb strength (hand-held dynamometer) in adults with patellofemoral pain syndrome (PFPS).
Patients with chronic PFPS will be randomized (1:1:1) into:
General MET group: standard non-specific hamstring MET stretch
Medial MET group: targeted medial-hamstring MET stretch
Lateral MET group: targeted lateral-hamstring MET stretch
All groups receive:
TENS: 20 min asymmetric biphasic square-pulse, 120 μs pulse width, 180 Hz, electrodes around patella (5-7 cm apart)
Strengthening: 3×/week for 4 weeks; hip/knee exercises, start 3×10 reps → 3×20, progress with weights or resistance bands.
Outcomes are measured pre-intervention and at 4 weeks. Analysis by mixed-design MANOVA (α \< 0.05).
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
* General hamstring Muscle energy technique (MET) * TENS 20 min * Hip/knee strengthening program
Device: Transcutaneous Electrical Nerve Stimulation Device · Other: Strength exercises for lower limb · Other: Hamstring Stretch Muscle Energy Technique(MET) (General )
* Medial hamstring MET * TENS 20 min * Hip/knee strengthening program
Device: Transcutaneous Electrical Nerve Stimulation Device · Other: Strength exercises for lower limb · Other: Medial Hamstring Muscle energy technique(MET) stretch
* Lateral hamstring MET * TENS 20 min * Hip/knee strengthening program
Device: Transcutaneous Electrical Nerve Stimulation Device · Other: Strength exercises for lower limb · Other: Lateral hamstring Muscle Energy Technique(MET)Stretch
Each participant will receive 20 minutes of TENS, Electrodes will be positioned around the patella with a 5 - 7 cm distance in between, The TENS settings include a continuous asymmetric biphasic square-pulse wave, a pulse width of 120 microseconds, and a pulse rate of 180 Hz.
Also known as: TENS
Each participant will receive progressive strengthening program targeting the hip and knee, begin with 3 sets of 10 repetitions and progress to 3 sets of 20 repetitions.
The participant will be supine and the leg will be taken into hip flexion until a tightness is felt then patient will be asked to push down with his lower leg and hold the contraction for 10 seconds then relax for 2 to 3 seconds then the therapist will take the patient's leg into further flexion for 30 seconds this will be repeated for 3 times each session .
Also known as: Non-Specific hamstring stretch MET
The Participant will be supine' then the therapist will take his leg in flexion, abduction and external rotation at the same time until he feels tightness then he will ask the patient to push his leg down and in or toward him and hold the contraction for 10 seconds then relax for 2 to 3 seconds then therapist will take the patient's leg in more abduction 'external rotation and flexion for 30 seconds, this will be repeated for 3 times each session
Also known as: specific medial hamstring MET stretch
The Participant will be supine' then the therapist will take his leg in flexion, adduction and internal rotation at the same time until he feels a tightness then he will ask the patient to push his leg down and out or away from him him and hold the contraction for 10 seconds then relax for 2 to 3 seconds then therapist will take the patient's leg in more adduction 'internal rotation and flexion for 30 seconds, this will be repeated for 3 times each session
Also known as: Specific lateral hamstring MET stretch
hamstring flexibility (knee extension range of motion )
measuring knee extension range of motion(hamstring flexibility) by active knee extension test using kinovea software
Time frame: 4 weeks
Arabic Kujala Anterior knee pain score
Arabic Kujala Anterior knee pain score is used to measure pain and functional activities in anterior knee pain patients consisting of 13 questions, the Patient will be asked to mark the most suitable answer for him. Each answer has points up to 5 or 10, and the total score is 100. The higher the score, the better for the patient.
Time frame: 4 weeks
pain intensity by visual analogue scale (VAS)
from 0 to 10 centimeter line patient will detect on it the usual pain felt and the worst pain during the day
Time frame: 4 weeks
lower limb strength using handheld dynamometer
using handheld dynamometer to assessment the strength of hip abductor, extensors, external rotators and knee extensors
Time frame: 4 weeks
Plan to share: No
Start is estimated for Jun 2025; primary completion for Oct 2025, 4 months later.
Of 153 non-industry interventional studies with no phase under Patellofemoral Pain Syndrome, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 20. This study's planned 4 months is below that.
Counting every sponsor, half of 157 studies reached it within 11 months; a quarter within 4 and three quarters within 21.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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Patellofemoral Pain Syndrome →