An observational study in Spinal Aneshtesia, General Anesthetic and Inflammation, sponsored by Tokat Gaziosmanpasa University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2025-05-25.
Sponsored by Tokat Gaziosmanpasa University · Observational
In total knee arthroplasty, surgical and anesthetic procedures can lead to a significant increase in systemic inflammation. This procedure is frequently performed under either general or spinal anesthesia. However, studies investigating the effect of anesthesia type on systemic inflammation have shown conflicting results. The Systemic Inflammatory Response Index (SIRI) and the Systemic Immune-Inflammation Index (SII) provide important information about the extent of systemic inflammation. This study aimed to investigate the effects of general and spinal anesthesia on perioperative changes in SII and SIRI during total knee arthroplasty. Between January 2020 and April 2025, data from 849 patients who underwent total knee arthroplasty were retrospectively reviewed. Patients received either spinal anesthesia (Group S) or general anesthesia (Group G). The groups were compared in terms of changes in perioperative SII and SIRI (ΔSII and ΔSIRI), total opioid consumption, postoperative complications, and length of hospital stay.
3,512 studies on the registry are indexed under Inflammation; 640 are open to participants now.
This study's enrollment of 849 is above the median of 95 across 913 observational studies indexed under Inflammation.
Browse Inflammation studies →Tokat Gaziosmanpasa University is the lead sponsor of 170 studies on the registry; 38 are open to participants now.
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Between January 2020 and April 2025, data from 849 patients who underwent total knee arthroplasty were retrospectively reviewed.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underwent total knee arthroplasty under spinal anesthesia
Other: The effects of the groups on perioperative inflammation changes were compared.
Underwent total knee arthroplasty under general anesthesia
Other: The effects of the groups on perioperative inflammation changes were compared.
Between January 2020 and April 2025, data from 849 patients who underwent total knee arthroplasty were retrospectively reviewed. Preoperative hemogram values were obtained during routine anesthesia clinic evaluation, typically one day prior to surgery. Postoperative hemogram samples were collected on the day of surgery (postoperative day 0), within 4 to 12 hours after the procedure. Blood parameters included neutrophil, lymphocyte, monocyte, and platelet counts. Based on these values, inflammatory indices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were calculated.
Systemic immune inflammation index (SII) and systemic inflammatory response index (SIRI)
SII = neutrophil X platelet / lymphocyte count and the SIRI = neutrophil X monocyte / lymphocyte count
Time frame: Preoperative hemogram values were obtained during routine anesthesia clinic evaluation, typically one day prior to surgery. Postoperative hemogram samples were collected on the day of surgery (postoperative day 0), within 4 to 12 hours after the procedur
Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR)
NLR = neutrophil / lymphocyte and PLR= platelet / lymphocyte
Time frame: Preoperative hemogram values were obtained during routine anesthesia clinic evaluation, typically one day prior to surgery. Postoperative hemogram samples were collected on the day of surgery (postoperative day 0), within 4 to 12 hours after the procedur
Total amount of opioids consumed postoperatively
Total opioid consumption was calculated by converting all opioid doses to morphine milligram equivalents
Time frame: Total amount of opioids requirement within the first 24 postoperative hours
Plan to share: Yes — The data used to support the findings of this study can be obtained from the corresponding author on request.
Supporting information: Statistical analysis plan
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Ran from Jan 2020 to primary completion in Apr 2025, 63 months.
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This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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