The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis

Browse trials for

• Periodontitis 1,635
• Periodontal Pocket 126

Periodontitis

1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.

This study's planned enrollment of 60 is above the median of 45 across 1,191 interventional studies indexed under Periodontitis.

Lead sponsor

Mansoura University is the lead sponsor of 1,077 studies on the registry; 183 are open to participants now.

Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Study arms

• Experimental
  Group 1: Periodontitis patients treated by NSPT and chitosan nanoparticles gel loaded by quercetin

  selected patients receive SRP and chitosan nanoparticles gel loaded by quercetin

  Drug: NSP and chitosan nanoparticles gel loaded by quercetin

• Experimental
  Group 2: Periodontitis patients treated by NSPT and chitosan nanoparticles gel.

  selected patients receive SRP and chitosan nanoparticles gel

  Drug: NSP and chitosan nanoparticles gel

• Active comparator
  Group 3: Periodontitis patients treated by NSPT only

  NSPT

  Procedure: scaling and root planning

• No intervention
  Group 4: Periodontally healthy subjects.

  healthy individual act as control group

Interventions

• DrugNSP and chitosan nanoparticles gel loaded by quercetin

  NSP and chitosan nanoparticles gel loaded by quercetin

• DrugNSP and chitosan nanoparticles gel

  NSP and chitosan nanoparticles gel

• Procedurescaling and root planning

  NSPT

Primary outcomes

1. assessment clinical attachment level by UNC 15 periodontal probe

   Time frame: 12 weeks

Secondary outcomes

1. assessment of the gingival crevicular levels of NF-κB by Elisa kit

   Time frame: 12 weeks

Individual participant data

Plan to share: Undecided — Clinical effect of Quercetin in treatment of periodiontal pocket