An interventional study of Thoracic epidural block and Paravertebral block in Thoracic Epidural Anesthesia, Paravertebral Block and Awake Thoracotomy, sponsored by Cairo University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2025-05-16.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This study aims to compare paravertebral block and thoracic epidural in awake thoracotomy.
Pain can often persist after thoracotomy, and the incidence of chronic pain is high, with studies revealing that 30% to 50% of patients still experience pain up to five years after surgery.
Thoracic epidural blockade (TEB) blocks nerves that supply the chest with local anesthetic bilaterally, at the spinal cord level. It acts by reducing the onward transmission of painful nerve signals, but may not abolish them altogether. Paravertebral blockade (PVB) involves injecting local anesthetic into the paravertebral space, which contains spinal nerves (and sometimes even extension of the dura), white and grey rami communicantes, the sympathetic chain, and intercostal vessels, on the side of surgery.
386 studies on the registry are indexed under Aortic Dissection; 117 are open to participants now.
This study's planned enrollment of 60 is below the median of 84 across 198 interventional studies indexed under Aortic Dissection.
Browse Aortic Dissection studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients will preoperatively receive an awake thoracic epidural block.
Other: Thoracic epidural block
Patients will preoperatively receive a paravertebral block.
Other: Paravertebral block
Patients will preoperatively receive an awake thoracic epidural block.
Patients will preoperatively receive a paravertebral block.
Intraoperative fentanyl consumption
Additional bolus doses of fentanyl 0.5µg/kg will be given if the mean arterial blood pressure or heart rate rises above 20% of baseline levels.
Time frame: Intraoperatively
Time to the 1st rescue analgesia
Time to first request of rescue analgesia will be assessed from the end of surgery till first dose of morphine administrated.
Time frame: 48 hours postoperatively
Mean arterial pressure
Mean arterial pressure will be recorded at baseline, and every 15min till the end of surgery
Time frame: Till the end of surgery (Up to 2 hours)
Heart rate
Heart rate will be recorded at baseline, and every 15min till the end of surgery
Time frame: Till the end of surgery (Up to 2 hours)
Total morphine consumption
If numeric rating scale (NRS)\>3 at rest will be observed, rescue analgesia via IV morphine 3 mg boluses will be administered.
Time frame: 48 hours postoperatively
Degree of pain
The patients will be instructed how to report pain by the numeric rating scale (NRS) \[on a scale from (0 to 10), zero means no pain and ten means the worst pain\]. NRS will be measured at post-anesthesia care unit (PACU), 1, 2, 4, 8, 12, 18, 24, 36, 48 hours postoperatively at rest and movement
Time frame: 48 hours postoperatively
Degree of patient satisfaction
Degree of patient satisfaction will be assessed on a 5-point Likert scale patient satisfaction (1, extremely dissatisfied; 2, unsatisfied; 3, neutral; 4, satisfied; 5, extremely satisfied)
Time frame: 48 hours postoperatively
Incidence of adverse events
Incidence of adverse events such as nausea, vomiting, respiratory depression, hypotension and bradycardia
Time frame: 48 hours postoperatively
Plan to share: Yes — The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Supporting information: Study protocol
No publications or documents are linked to this record.
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Cairo University