An observational study in Acute Coronary Syndrome and Chronic Coronary Syndrome, sponsored by Second Affiliated Hospital of Wenzhou Medical University. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-07-25.
Sponsored by Second Affiliated Hospital of Wenzhou Medical University · Observational
The goal of this study is to conduct analyses the changes of cell growth factors, inflammatory factors, metabolites, plasma proteome, etc. in the blood of patients with ACS (acute coronary syndrome), as well as their correlations with the disease prognosis, based on multi-omics or other related research methods. The main questions it aims to answer are:
The growth factors that have significant changes in the peripheral blood of the ACS population, especially fibroblast growth factors? Inflammatory factors and chemokines related to the onset of ACS? The metabolites and proteins that are significantly altered in the peripheral blood after the onset of ACS? Researchers will compare ACS population to CCS (Chronic Coronary Syndrome) population, and control group (patients without coronary artery stenosis, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy).The peripheral venous blood from the participants will be collected within 24 hours after their admission to the hospital.
1,461 studies on the registry are indexed under Acute Coronary Syndrome; 267 are open to participants now.
This study's planned enrollment of 310 is below the median of 500 across 561 observational studies indexed under Acute Coronary Syndrome.
Browse Acute Coronary Syndrome studies →Second Affiliated Hospital of Wenzhou Medical University is the lead sponsor of 133 studies on the registry; 44 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who presented to Lishui Central Hospital (Fifth Affiliated Hospital of Wenzhou Medical University) due to cardiac discomfort or other related symptoms were consecutively enrolled in the present study.
For ACS group STEMI
NSTEMI
UA
Exclusion Criteria:
those with a condition of Acute Coronary Syndrome
patients without coronary artery disease, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy
those with a condition of Chronic Coronary Syndrome
circulating fibroblast growth factors (FGFs) levels
examining the circulating fibroblast growth factors levels in the peripheral venous blood of the participants
Time frame: within 24 hours of admission to the hospital
circulating inflammatory cytokines levels
examining the circulating inflammatory cytokines levels in the peripheral venous blood of the participants
Time frame: within 24 hours of admission to the hospital
circulating chemokines levels
examining the circulating chemokines levels in the peripheral venous blood of the participants
Time frame: within 24 hours of admission to the hospital
circulating Cytochrome C level
examining the circulating cytochrome c levels in the peripheral venous blood of the participants
Time frame: within 24 hours of admission to the hospita
circulating mitochondrial DNA levels
examining the circulating mitochondrial DNA levels in the peripheral venous blood of the participants
Time frame: within 24 hours of admission to the hospital
circulating malondialdehyde levels
examining the circulating malondialdehyde levels in the peripheral venous blood of the participants
Time frame: within 24 hours of admission to the hospital
the relationship between FGFs/inflammatory cytokines/chemokines and troponin I (TnI)
performed correlation analyses between the circulating levels of FGFs/inflammatory cytokines/chemokines and TnI
Time frame: within 24 hours of admission to the hospital
the relationship between FGFs/inflammatory cytokines/chemokines and brain natriuretic peptide (BNP)
performed correlation analyses between the circulating levels of FGFs/inflammatory cytokines/chemokines and BNP
Time frame: within 24 hours of admission to the hospital
the relationship between FGFs/inflammatory cytokines/chemokines and lactate dehydrogenase (LDH)
performed correlation analyses between the circulating levels of FGFs/inflammatory cytokines/chemokines and LDH
Time frame: within 24 hours of admission to the hospital
the relationship between FGFs/inflammatory cytokines/chemokines and left ventricular ejection fraction (LVEF)
performed correlation analyses between the circulating levels of FGFs/inflammatory cytokines/chemokines and LVEF
Time frame: within 24 hours of admission to the hospital
the relationship between FGFs/inflammatory cytokines/chemokines and mitochondrial DNA (mitoDNA)
performed correlation analyses between the circulating levels of FGFs/inflammatory cytokines/chemokines and mitochondrial DNA contents
Time frame: within 24 hours of admission to the hospital
the relationship between FGFs/inflammatory cytokines/chemokines and cytochrome c
performed correlation analyses between the circulating levels of FGFs/inflammatory cytokines/chemokines and cytochrome c
Time frame: within 24 hours of admission to the hospital
the relationship between FGFs/inflammatory cytokines/chemokines and malondialdehyde
performed correlation analyses between the circulating levels of FGFs/inflammatory cytokines/chemokines and malondialdehyde
Time frame: within 24 hours of admission to the hospital
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Second Affiliated Hospital of Wenzhou Medical University