An observational study in Volatile Organic Compound and Gastrointestinal Hemorrhage, sponsored by Beijing 302 Hospital. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-03-14.
Sponsored by Beijing 302 Hospital · Observational
This study aims to develop a non-invasive and rapid diagnostic technology for acute upper gastrointestinal bleeding (AUGIB) by analyzing volatile organic compounds (VOCs) in exhaled breath. Clinically confirmed patients will be divided into three groups (no bleeding, minor bleeding, major bleeding) based on endoscopic findings. VOC profiles will be analyzed to construct a predictive model, validated for sensitivity and specificity (both targets ≥0.7). This approach addresses the limitations of endoscopy in emergency or resource-limited settings, improving diagnostic efficiency and reducing mortality.
Acute upper gastrointestinal bleeding (AUGIB) is a common emergency with an annual incidence of 100-180/100,000 and mortality of 2%-15%. Endoscopy, the gold standard, is invasive and equipment-dependent, limiting its use in primary care or emergencies. Exhaled breath VOCs analysis, a non-invasive and portable method, has been applied in other diseases but not yet explored for AUGIB.
Objectives:
339 studies on the registry are indexed under Gastrointestinal Hemorrhage; 79 are open to participants now.
This study's planned enrollment of 200 is close to the median of 200 across 116 observational studies indexed under Gastrointestinal Hemorrhage.
Browse Gastrointestinal Hemorrhage studies →Beijing 302 Hospital is the lead sponsor of 86 studies on the registry; 31 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients requiring endoscopy for suspected AUGIB
Exclusion Criteria:
No blood in the upper gastrointestinal tract
Device: Gastroscopy · Diagnostic Test: Gas Chromatography - Mass Spectrometry
A little blood in the upper gastrointestinal tract
Device: Gastroscopy · Diagnostic Test: Gas Chromatography - Mass Spectrometry
Plenty of blood in the upper gastrointestinal tract
Device: Gastroscopy · Diagnostic Test: Gas Chromatography - Mass Spectrometry
Gastroscopy for all included patients
Using a patient's exhaled breath test with Gas Chromatography - Mass Spectrometry
Sensitivity and specificity of the diagnostic model
targets ≥0.7
Time frame: 4 months
Identification of key VOCs
e.g., aldehydes, ketones
Time frame: 4 months
Differences in VOC concentrations across 3 bleeding severity groups
Different VOCs
Time frame: 4 months
No study locations are listed for this record.
This study is not yet recruiting, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Beijing 302 Hospital