An interventional study of Morning high-intensity interval exercise and Evening high-intensity interval exercise in Post-Exercise Hypotension, Ambulatory Blood Pressure Monitoring and High-intensity Interval Exercise, sponsored by University of Guelph. Completed at 1 site in Canada. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-11-27.
Sponsored by University of Guelph · Not applicable, Interventional, and Prevention
The goal of this clinical trial was to assess the effects of morning vs. evening high-intensity interval exercise on the magnitude of the morning blood pressure surge in young healthy adults. The main questions it aimed to answer were:
Participants came in and completed a bout of high-intensity interval exercise in the morning (8-10 am) and evening (5-7 pm) as well as a no exercise control, and ambulatory blood pressure was assessed for 24 hours afterwards.
Introductory Visit:
Participants came in for 4 visits. The first visit was an introductory visit where chronotype, eligibility for exercise, and anthropometrics were measured. This was followed by a maximal incremental exercise test to determine aerobic capacity (i.e., V̇O2peak) on a cycle ergometer, and instrumentation of an ambulatory blood pressure monitor for familiarization during daily activities and sleep.
Intervention Visits:
Three intervention visits (control, morning exercise, and evening exercise) were completed. The order was randomized using and each visit was separated by a minimum of 36 hours. Each intervention visit began by obtaining the participant's resting blood pressure and heart rate and ended with the instrumentation of the ambulatory blood pressure monitor. No exercise was performed during the control visit. The morning exercise visit included a bout of high-intensity interval exercise between 8-10 am and the evening exercise visit included a bout of high-intensity interval exercise between 5-7 pm. The high-intensity interval exercise protocol consisted of a light intensity, 3-minute warm-up at 15% peak power followed by ten 1-minute work intervals at 80% of peak power, with each interval separated by 1-minute rest intervals at 15% peak power. A 3-minute cool down was performed at 15% peak power.
22 studies on the registry are indexed under Post-Exercise Hypotension; 2 are open to participants now.
This study's enrollment of 31 is above the median of 21 across 22 interventional studies indexed under Post-Exercise Hypotension.
Browse Post-Exercise Hypotension studies →University of Guelph is the lead sponsor of 70 studies on the registry; 5 are open to participants now.
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Exclusion:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
No exercise was performed and ambulatory blood pressure was assessed for 24 hours.
High-intensity interval exercise was performed between 8-10 am and ambulatory blood pressure was assessed for 24 hours after.
Other: Morning high-intensity interval exercise
High-intensity interval exercise was performed between 5-7 pm and ambulatory blood pressure was assessed for 24 hours after.
Other: Evening high-intensity interval exercise
High-intensity interval exercise was performed between 8-10 am
High-intensity interval exercise was performed between 5-7 pm
Morning blood pressure surge
The difference between morning blood pressure (the mean of the 4 blood pressure readings after awakening) and sleep-trough blood pressure (the mean of the lowest blood pressure during sleep and two adjacent blood pressure readings).
Time frame: Through study completion, an average of 4 weeks.
Nighttime blood pressure dip
The percent difference between daytime blood pressure (average of all blood pressure readings when participants reported being awake) and nighttime blood pressure (average of all blood pressure readings when the participant reported being asleep).
Time frame: Through study completion, an average of 4 weeks.
Plan to share: Yes — Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices).
Supporting information: Study protocol
Time frame: After publication; unending.
Access criteria: Investigators whose proposed use of the data has been approved by an independent review committee ("learned intermediary") identified for this purpose.
No publications or documents are linked to this record.
This study is completed, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.
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University of Guelph