An Early Phase 1 interventional study of Aerobic Exercise and alpha-FMH in Postexercise Hypotension, sponsored by University of Oregon. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-23.
Sponsored by University of Oregon · Early Phase 1, Interventional, and Basic science
This study is investigating the role of histamine in generating adaptation to exercise
Exercise promotes and maintains healthy cardiovascular, musculoskeletal, and metabolic function, but the signals and mechanisms which transduce these effects are poorly understood. Histamine plays a role in some of the positive benefits of exercise. The goal of this study is to determine the factors that regulate exercise's effects on endothelial and vascular function, with a focus on histamine released from mast cells in skeletal muscle. Participants will perform exercise or participate in interventions like heating that may replicate some of the effects of exercise. During most experiments, investigators will insert an intravenous catheter in an arm vein and microdialysis probes in the leg, collect dialysate from the microdialysis probe and blood from the vein, record noninvasive measures, and have the participants perform exercise or undergo heating.
22 studies on the registry are indexed under Post-Exercise Hypotension; 2 are open to participants now.
This study's planned enrollment of 80 is above the median of 21 across 22 interventional studies indexed under Post-Exercise Hypotension.
Browse Post-Exercise Hypotension studies →University of Oregon is the lead sponsor of 75 studies on the registry; 18 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Blood and skeletal muscle microdialysate collected during dynamic knee-extension exercise
Behavioral: Aerobic Exercise
Blood and skeletal muscle microdialysate collected during local and/or whole body heating
Drug: alpha-FMH
Blood and urine collected during recovery from two modalities of exercise (This arm is now CLOSED)
Behavioral: Resistance and Aerobic Exercise
Muscle perfusion measured during aerobic exercise (This arm is now CLOSED)
Behavioral: Aerobic Exercise · Drug: Antihistamine
Subjects will complete a single bout of aerobic exercise.
Subjects will undergo either local heating with diathermy or whole body heating with far-infrared sauna.
Also known as: Heating
Subjects will complete bouts of resistance and aerobic exercise.
Subjects will complete a single bout of aerobic exercise under placebo vs antihistamine conditions.
Percentage of mast cell degranulation
Beta-hexosaminidase release from mast cells in mast cell degranulation bioassay when exposed to intramuscular dialysate from exercising individuals
Time frame: One hour
Histamine concentration
Histamine concentration in intramuscular dialysate
Time frame: One hour
Histamine metabolites
Concentration of histamine metabolites in blood and urine
Time frame: 24 hours
Muscle perfusion
Skeletal muscle tissue oxygen index
Time frame: One hour
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No
Ran from Jul 2021 to primary completion in Dec 2025, 53 months.
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This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Antihistamines
University of Oregon