An interventional study of Combined strength training and Dynamic strength training in Dynamic Strength Exercise Session, Isometric Strength Exercise Session and Combined Exercise Session, sponsored by Federal University of Rio Grande do Sul. Completed at 1 site in Brazil. Open to participants aged 30 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-07-28.
Sponsored by Federal University of Rio Grande do Sul · Not applicable, Interventional, and Treatment
Dynamic strength training (DST) is widely recognized for promoting neuromuscular adaptations such as increased strength and hypertrophy. It is currently endorsed by treatment and prevention guidelines for systemic arterial hypertension (SAH) due to its significant effect on lowering blood pressure (BP). However, when comparing BP reduction values, isometric strength training (IST) stands out with greater magnitudes of BP reduction, although without the neuromuscular adaptations seen in DST. Given their similarities, a combination of these strategies through combined strength training (CST) is possible but has not yet been evaluated. The researchers hypothesized that CST may have an additive effect compared with DST and IST alone in reducing ambulatory BP. Therefore, the objective of the present thesis was to evaluate and compare the effects of CST, DST, and IST on regulatory variables of ambulatory BP in medicated middle-aged hypertensive patients. This thesis is structured in two parts: (1) a crossover study with medicated middle-aged hypertensive patients to identify autonomic, endothelial, and vascular responses related to ambulatory BP after a single session of CST, DST, and IST; and (2) a randomized clinical trial to assess the chronic effects of CST, DST, and IST on regulatory variables of ambulatory BP in medicated middle-aged hypertensive patients.
"This thesis is structured in two sequential stages:
A randomized crossover trial involving medicated middle-aged hypertensive patients to identify autonomic, endothelial, and vascular responses on ambulatory blood pressure following a single session of Combined Strength Training (CST), Dynamic Strength Training (DST), and Isometric Strength Training (IST), compared to a control session.
A randomized controlled trial to assess the chronic effects (8 weeks) of CST and DST on the regulatory variables of ambulatory blood pressure in medicated middle-aged hypertensive patients, compared to a non-exercising control group."
22 studies on the registry are indexed under Post-Exercise Hypotension; 2 are open to participants now.
This study's enrollment of 60 is above the median of 21 across 22 interventional studies indexed under Post-Exercise Hypotension.
Browse Post-Exercise Hypotension studies →Federal University of Rio Grande do Sul is the lead sponsor of 121 studies on the registry; 20 are open to participants now.
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Clinical diagnosis of stage 1 or stage 2 hypertension, according to current guidelines.
Sedentary lifestyle (no participation in structured exercise training for at least 6 months).
Age between 18 and 60 years. Stable antihypertensive pharmacological treatment for at least 4 weeks before enrollment.
Ability to perform resistance exercise.
Exclusion Criteria:
Symptomatic cardiovascular disease. Heart failure. Unstable angina. Uncontrolled diabetes mellitus ( > 8%). Renal insufficiency. Musculoskeletal disorders or physical limitations that contraindicate resistance exercise.
Changes in antihypertensive medication within the 4 weeks prior to enrollment or during the study protocol.
Current smoking. Excessive alcohol consumption.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
8 dynamic strength exercises, with 14 repetitions, 3 sets, 1 second concentric phase and 2 seconds eccentric phase. 30 seconds of rest between sets and 1 minute and 30 seconds of rest between exercises.
Other: Dynamic strength training
8 isometric strength exercises. 10 seconds of isometric strength. 3 sets, 1 second concentric and 2 eccentric. 30 seconds rest between sets and 1 minute and 30 seconds rest between exercises.
Other: Acute Isometric Exercise Session.
The control group consists of maintaining their habits for 8 weeks, without strength exercises.
Other: Control Session and Follow-up
8 resistance exercises combining dynamic repetitions with isometric components. Protocol: 3 sets of 11 repetitions, with a concentric phase of 1 second and an eccentric phase of 2 seconds combined with 10 seconds of isometric hold at the end of each set. Includes 30 seconds of rest between sets and 90 seconds between exercises.
Other: Combined strength training
Participants in this group undergo two phases. Phase 1: A single acute exercise session consisting of 8 resistance exercises (3 sets of 11 repetitions with a 10-second isometric hold at the end of each set; 1s concentric/2s eccentric phases). Phase 2: An 8-week chronic intervention period, performing the same combined protocol 3 times a week, with intensity progressing from 50% to 65% of 1RM.
Participants in this group go through two phases. Phase 1: A single acute exercise session consisting of 8 resistance exercises (3 sets of 14 repetitions, 1 second concentric phase and 2 seconds eccentric phase, 30 seconds of rest between sets and 90 seconds between exercises) at 50% of 1RM. Phase 2: An 8-week chronic intervention period, performing the same dynamic resistance protocol 3 times a week, with intensity progressing from 50% to 65% of 1RM.
Participants in this group undergo a single acute exercise session consisting of 8 resistance exercises performed isometrically. The protocol includes 3 sets per exercise, with each set consisting of a 10-second static contraction at 50% of 1RM, with 30 seconds of rest between sets and 90 seconds between exercises
Participants in this group undergo two phases. Phase 1: A single acute control session consisting of quiet rest in a seated position for the same duration as the exercise sessions. Phase 2: An 8-week follow-up period where participants maintain their usual daily activities and pharmacological treatment without any structured exercise program.
24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean)
Average systolic blood pressure measured over a 24-hour period using an automated ambulatory monitor (ABPM). This measure assesses the chronic effect of the 8-week training protocols compared to baseline.
Time frame: Baseline and 8 weeks
Acute 24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean)
Average systolic blood pressure measured over a 24-hour period following a single session of each intervention (Dynamic, Combined, Isometric, and Control) to evaluate post-exercise hypotension. This was conducted in a crossover design.
Time frame: 24 hours post-intervention
Acute Post-Exercise Blood Pressure Response
Systolic and diastolic blood pressure measured at rest (pre-intervention) and at 30 and 60 minutes following a single exercise session to evaluate the immediate post-exercise hypotension (PEH).
Time frame: Baseline, 30 minutes, and 60 minutes post-exercise.
Vascular Endothelial Function - Chronic (Flow-Mediated Dilation)
Percentage of brachial artery dilation measured via high-resolution ultrasound to evaluate the chronic adaptations of vascular endothelial function after the 8-week intervention.
Time frame: Baseline and 8 weeks
Vascular Endothelial Function - Acute Response (Flow-Mediated Dilation)
Acute changes in the percentage of brachial artery dilation following a single session of exercise. This measure evaluates the transient endothelial response at different time points.
Time frame: Baseline, 30 minutes, and 60 minutes post-exercise.
Cardiac Autonomic Modulation - Chronic (Heart Rate Variability)
Analysis of heart rate variability (HRV) parameters in both time and frequency domains (e.g., SDNN, RMSSD, LF, HF) to evaluate chronic adaptations in cardiac autonomic control after the 8-week intervention.
Time frame: Baseline and 8 weeks.
Cardiac Autonomic Modulation - Acute Response (Heart Rate Variability)
Acute changes in heart rate variability parameters following a single session of exercise. This evaluates the immediate autonomic recovery and sympathetic-vagal balance at different time points.
Time frame: Baseline, 30 minutes, and 60 minutes post-exercise.
Office Blood Pressure Adaptation (Weekly Progression)
Assessment of the progression of resting systolic and diastolic blood pressure measured before exercise sessions throughout the 8-week intervention to evaluate the time course of blood pressure adaptations.
Time frame: Baseline and weekly for 8 weeks.
Blood-based Biomarkers of Cardiovascular Health
Analysis of blood samples to evaluate biochemical markers related to cardiovascular health, such as markers of inflammation, oxidative stress, or nitric oxide bioavailability, to investigate the mechanisms underlying blood pressure changes.
Time frame: Baseline and 8 weeks
Acute Blood-based Biomarkers Response
Analysis of blood samples to evaluate the acute response of biochemical markers related to cardiovascular and endothelial health (e.g., nitric oxide metabolites, inflammatory cytokines, or oxidative stress markers) following a single session of exercise.
Time frame: Baseline, 30 minutes, and 60 minutes post-exercise.
Body Composition (Skinfold Thickness)
Assessment of body composition using skinfold thickness measurements to estimate body fat percentage and lean body mass. This measure monitors physical changes and ensures that any observed blood pressure adaptations are not solely due to changes in body fat or weight.
Time frame: Baseline and 8 weeks
Plan to share: No — Individual participant data will not be shared to ensure the privacy and confidentiality of the participants, in accordance with the local institutional review board and data protection regulations.
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This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Federal University of Rio Grande do Sul →