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CompletedNCT06687187GastricUpdated Nov 13, 2024

Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients

An observational study in Gastric Reflux, sponsored by Zulekha Hospitals. Completed at 1 site in Egypt. Open to participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2024-11-13.

Sponsored by Zulekha Hospitals · Observational

Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
3
Ages
20 Years to 60 Years
Sex
All
01

Study summary

A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.

Read the detailed description

Participants were categorized into three groups: Group I and Group II received neostigmine 1 mg and 2 mg, respectively, and a control group received 10 ml of normal saline. All participants received an intravenous administration of 10 mg of metoclopramide. GRV was measured every 3 hours before enteral feeding. aspiration through nasogastric (NG) or orogastric (OG) tubes was done before the next due bolus of feeding.

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Conditions studied

  • Gastric Reflux
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In context

Gastroesophageal Reflux

1,086 studies on the registry are indexed under Gastroesophageal Reflux; 187 are open to participants now.

This study's enrollment of 3 is below the median of 175 across 304 observational studies indexed under Gastroesophageal Reflux.

Browse Gastroesophageal Reflux studies →

Lead sponsor

Zulekha Hospitals is the lead sponsor of 6 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

The study included 124 patients aged between 20 and 60 years requiring enteral feeding via nasogastric (NG) or orogastric (OG) tubes

Eligibility criteria

Inclusion Criteria:

  • patients with a GRV >120ml
  • a normal heart rateExclusion Criteria
  • absence of comorbidities such as diabetes and renal failure. exclusion Criteria:
  • Patients exhibiting new-onset arrhythmias or heart block
  • hypotension (systolic blood pressure less than 60 mmHg)
  • experiencing active gastrointestinal bleeding or receiving prokinetic medications 8-12 hours before the intervention
  • patients with a history of surgery in the gastrointestinal system in the past two weeks history of extrapyramidal manifestations
  • patients with electrolyte imbalance
  • pregnant patients,
05

Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
3 participants (actual)
Patient registry
No

Groups and cohorts

  • Group I

    received neostigmine 1 mg

    Drug: Neostigmine

  • Group II

    received neostigmine 2 mg

    Drug: Neostigmine

  • Group III

    received normal saline

Interventions

  • two groups (Group I, n= 41) and (Group II, n= 43) received varying doses of neostigmine (1 mg and 2 mg respectively

06

What researchers measure

Primary outcomes

  1. The risk of aspiration

    The risk of aspiration in ICU patients on enteral feeding via vaso-gastric or oro-hastric tubes

    Time frame: december 2022 to may 2024

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Study locations

1 site
  • Al-Azhar faculty of medicine
    Cairo, 12546, Egypt
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 13, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06687187
Lead sponsor
Zulekha Hospitals
Responsible party
Sponsor
First posted
Nov 13, 2024
Start date
Dec 1, 2022
Primary completion
Apr 1, 2024
Completion
May 1, 2024
Last update
Nov 13, 2024

Study contacts

abdalla e hassan, lecturer
principal investigator · lecturer

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.

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