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Not yet recruitingNCT06678334Updated Nov 7, 2024

Characteristic Transcriptomic, Proteomic and Metabolomic Molecular Studies of Nasal Secretions From Chronic Rhinitis

An observational study in Chronic Rhinitis, sponsored by The First Affiliated Hospital with Nanjing Medical University. Not yet recruiting. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2024-11-07.

Sponsored by The First Affiliated Hospital with Nanjing Medical University · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
1,000
Ages
18 Years to 65 Years
Sex
All
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Study summary

Chronic rhinitis is a common chronic nasal mucosal inflammatory disease. Its clinical symptoms and severity are diverse, mainly including allergic rhinitis, local allergic rhinitis, non-allergic rhinitis with hypereosinophilia syndrome and idiopathic rhinitis. All kinds of rhinitis have clinical symptoms such as nasal congestion, runny nose, sneezing, and nasal itching, but the causes are different. At present, the complicated diagnostic methods of different subtypes of chronic rhinitis are an important factor restricting the improvement of clinical diagnosis and treatment. Based on the found key markers of each subtype of chronic rhinitis, the establishment of a non-invasive classification diagnostic method of chronic rhinitis with nasal secretion as the core is of great practical significance for optimizing the existing clinical diagnosis system and improving the efficiency of clinical diagnosis

Read the detailed description

To study the characteristic transcriptome, proteome and metabolome molecules of nasal secretions of different subtypes of chronic rhinitis, and to establish a non-invasive diagnostic method for chronic rhinitis based on nasal secretions.Nasal secretions and blood were collected from patients with chronic rhinitis.

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Conditions studied

  • Chronic Rhinitis

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03

In context

Rhinitis

246 studies on the registry are indexed under Rhinitis; 22 are open to participants now.

This study's planned enrollment of 1,000 is above the median of 246 across 52 observational studies indexed under Rhinitis.

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Lead sponsor

The First Affiliated Hospital with Nanjing Medical University is the lead sponsor of 568 studies on the registry; 317 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All Patients in the First Affiliated Hospital, Nanjing Medical University and volunteering for this study

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Age 18-65 years old;
  2. Patients with chronic rhinitis in the Department of Otorhinolaryngology, the First Affiliated Hospital of Nanjing Medical University;
  3. Patients who are willing to provide specimens for free to promote the diagnosis of chronic rhinitis.

Exclusion criteria

Exclusion Criteria:

  1. Patients received , immunomodulatory drugs, antihistamines, and other treatments that may affect the study results within the past 1 month.
  2. Patients with unstable diseases (including severe asthma) and active immune system diseases;
  3. Smoking;
  4. Pregnant or lactating women; History of nasal surgery within 5.3 months;
  1. Patients with low compliance and refusing to accept specimen and questionnaire collection
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

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Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
1,000 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • chronic rhinitis

    In this study, no additional intervention was performed on the patients. Only nasal secretions and blood samples were collected from patients with chronic rhinitis in our hospital.

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What researchers measure

Primary outcomes

  1. The signature transcriptomic, proteomic, and metabolomic indicators or combinations of nasal secretions of different subtypes of chronic rhinitis

    The signature transcriptomic, proteomic, and metabolomic indicators or combinations of nasal secretions of different subtypes of chronic rhinitis, which have high sensitivity and specificity in the diagnosis of a specific chronic rhinitis.

    Time frame: 3 years

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: No — All the individual participant data only available to reasearchers participated in this study

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 7, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06678334
Responsible party
Cheng Lei (Professor, PhD, The First Affiliated Hospital with Nanjing Medical University) — Principal investigator
First posted
Nov 7, 2024
Start date
Nov 6, 2024 (estimated)
Primary completion
Dec 1, 2028 (estimated)
Completion
Dec 1, 2032 (estimated)
Last update
Nov 7, 2024

Study contacts

Lei Cheng, PhD
Contact
chenglei@jsph.org.cn
+8613776620807
Yanbing Chen MBBS, MBBS
Contact
1163259065@qq.com
+8615851875990
Lei Cheng, PhD
study director · The First Affiliated Hospital, Nanjing Medical University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.

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Discussion

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