An observational study in Chronic Rhinitis, sponsored by East and North Hertfordshire NHS Trust. Recruiting at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-04.
Sponsored by East and North Hertfordshire NHS Trust · Observational
Adult patients presenting with rhinitis who have persistent rhinitis despite appropriate medical treatment will receive a session of cryotherapy for the nose.
Historically, patients with chronic rhinitis (having symptoms such as frequent runny nose, congestion and or post- nasal drip) have had limited surgical treatment options such as a vidian neurectomy. Cryotherapy to the posterior nasal nerves is an emerging. minimally invasive treatment that can be administered under local anaesthetic in the outpatient setting. NICE has recommended that cryotherapy for chronic rhinitis is investigated further, particularly which subtypes of rhinitis and the duration of benefit. The investigators intend to assess the feasibility of the treatment in the setting of an NHS outpatients prior to potentially developing a randomised trial. Therefore there will be a small sample size of 5-10 patients. Patients who decide to take part may expect to have two additional visits to their standard care, these being: the treatment visit and a 6 week follow up in addition to a usual 3 month follow up. Patient Reported Outcome Measures will be taken at the additional visits as well as the usual visits. Investigator data such as duration of procedure and ease of administration will also be measured.
246 studies on the registry are indexed under Rhinitis; 22 are open to participants now.
This study's planned enrollment of 10 is below the median of 246 across 52 observational studies indexed under Rhinitis.
Browse Rhinitis studies →East and North Hertfordshire NHS Trust is the lead sponsor of 38 studies on the registry; 20 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients with chronic rhinitis leading to a watery nose
Inclusion Criteria: Adult patients presenting to the ENT Department at Lister Hospital with Rhinitis may be included. Symptoms may include nasal congestion and/or rhinorrhea with/without nasal itching and sneezing.
Exclusion Criteria:
Patients who present with a runny nose which is resistant to treatment, the intervention is cryotherapy to the back of the nose.
Device: Cryotherapy alone
Freezing treatment to the back of the nose, done in the clinic setting via the nasal cavity under local anaesthetic
Change in watery nasal discharge (runny nose)
as described by the patient
Time frame: 6 weeks and 3 months
Change in Sino-Nasal Outcome Test-22 (SNOT-22) Score
Change in patient-reported sinonasal symptoms and health-related quality of life, assessed using the SNOT-22 questionnaire. The total score ranges from 0 to 110, with higher scores indicating worse symptoms and quality of life.
Time frame: 6 weeks and 3 months
Change in Nasal Obstruction Symptom Evaluation (NOSE) Score
Change in patient-reported nasal obstruction symptoms, assessed using the NOSE questionnaire. The total score ranges from 0 to 100, with higher scores indicating worse nasal obstruction
Time frame: 6 weeks and 3 months
Change in Rhinitis Quality of Life Questionnaire (RQLQ) Score
Change in patient-reported rhinitis-related quality of life, assessed using the Rhinitis Quality of Life Questionnaire. Specify the questionnaire version and scoring range, including whether higher scores indicate worse quality of life
Time frame: 6 weeks and 3 months
Change in Endoscopic Visual Analogue Scale (VAS) Score
Change in nasal appearance assessed by the doctor using endoscopic examination and the study-defined Visual Analogue Scale. Specify the minimum and maximum score and whether higher scores indicate better or worse nasal appearance.
Time frame: 6 weeks and 3 months
Plan to share: No
Started Oct 2025 (actual). Primary completion is estimated for Oct 2026, 12 months after the start.
Of 13 observational studies under Rhinitis, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 36. This study's planned 12 months is above that.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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East and North Hertfordshire NHS Trust