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CompletedNCT06671808Updated Nov 4, 2024

HIV and Multi-Drug Resistant Tuberculosis: a Study on Clinical Outcomes

An observational study in HIV Infection and MDR-TB, sponsored by Zahedan University of Medical Sciences. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-11-04.

Sponsored by Zahedan University of Medical Sciences · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
222,128
Ages
18 Years and older
Sex
All
01

Study summary

This study aims to investigate the relationship between HIV infection and multi-drug resistant tuberculosis (MDR-TB) among affected individuals in Zahedan, Iran. It will involve a detailed analysis of patient demographics, clinical characteristics, and treatment outcomes to enhance understanding of this co-infection. The findings may inform better treatment strategies and healthcare policies for managing these diseases in similar populations.

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Conditions studied

03

In context

HIV Infections

4,734 studies on the registry are indexed under HIV Infections; 244 are open to participants now.

This study's enrollment of 222,128 is above the median of 200 across 781 observational studies indexed under HIV Infections.

Browse HIV Infections studies →

Lead sponsor

Zahedan University of Medical Sciences is the lead sponsor of 15 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The study population consists of adult individuals (aged 18 years and older) diagnosed with both HIV infection and multi-drug-resistant tuberculosis (MDR-TB). This meta-analysis synthesizes data from various studies conducted across multiple countries, including Brazil, the USA, Canada, India, Ethiopia, and several others. The population includes a diverse cohort of patients, reflecting various demographic characteristics such as age, sex, and geographical location.

The studies included in this meta-analysis feature participants with confirmed diagnoses of HIV and MDR-TB, with a focus on understanding the co-infection dynamics, treatment outcomes, and associated health challenges. Data extraction from these studies provides insight into the prevalence and impact of MDR-TB among HIV-positive patients, highlighting the importance of tailored

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adults (aged 18 years and older) diagnosed with both and multi-drug-resistant tuberculosis (MDR-TB).
  • Studies published in peer-reviewed journals.
  • Studies that provide data on the co-occurrence of HIV and MDR-TB.
  • Participants from diverse geographical regions to enhance generalizability.
  • Studies with clear definitions of MDR-TB according to WHO guidelines.

Exclusion criteria

Exclusion Criteria:

  • Studies that focus solely on drug-susceptible tuberculosis without MDR-TB.
  • Studies involving pediatric populations (under 18 years of age).
  • Non-original research such as reviews, editorials, and commentaries.
  • Studies lacking sufficient data on the co-occurrence of and MDR-TB.
  • Studies that do not adhere to ethical guidelines for human subjects or lack appropriate ethical approvals.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

HIV

The human immunodeficiency virus, which weakens the immune system.

Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.

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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
222,128 participants (actual)
Patient registry
No

Interventions

  • OtherExamination of HIV Infection in Patients with Multi-Drug Resistant Tuberculosis (MDR-TB)

    This meta-analysis examines the impact of HIV infection on the prevalence and outcomes of multi-drug resistant tuberculosis (MDR-TB) among affected populations. The analysis synthesizes data from multiple studies conducted across various countries, focusing on the correlation between HIV co-infection and MDR-TB rates, treatment outcomes, and demographic factors. The findings aim to enhance understanding of the complex interactions between HIV and MDR-TB, ultimately informing clinical practices and public health strategies.

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What researchers measure

Primary outcomes

  1. Prevalence of Multi-Drug Resistant Tuberculosis (MDR-TB) in HIV-Positive Patients

    This study aims to determine the prevalence of multi-drug resistant tuberculosis (MDR-TB) among patients co-infected with HIV. Data will be collected from various studies included in the meta-analysis, focusing on the incidence rates of MDR-TB in this population. The analysis will provide insights into the challenges faced in treating HIV-positive individuals with MDR-TB and highlight the need for targeted interventions.

    Time frame: Data collected over the course of the studies from 2006 to 2018.

07

Study locations

1 site
  • Zahedan University of Medical Sciences
    Zahedan, Sistan and Baluchestan 98167-43463, Iran, Islamic Republic of
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from May 2024 to primary completion in Aug 2024, 3 months.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 1, 2024
First posted
Nov 4, 2024
StartActual
May 15, 2024
Primary completionActual
Aug 22, 2024
CompletionActual
Sep 3, 2024
Last update
Nov 4, 2024
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Nov 4, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06671808
Lead sponsor
Zahedan University of Medical Sciences
Responsible party
Hamidreza Kouhpayeh (Assistant Professor, Zahedan University of Medical Sciences) — Principal investigator
First posted
Nov 4, 2024
Start date
May 15, 2024
Primary completion
Aug 22, 2024
Completion
Sep 3, 2024
Last update
Nov 4, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.

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Discussion

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