An interventional study of Platelet-rich fibrin (PRF) in Socket Preservation, sponsored by Zahedan University of Medical Sciences. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-15.
Sponsored by Zahedan University of Medical Sciences · Not applicable, Interventional, and Prevention
The goal of this clinical trial is to learn if platelet-rich fibrin (PRF), a substance made from a person's own blood, helps preserve the bone in the jaw after tooth extraction in adults. The main questions it aims to answer are:
Does PRF help reduce the loss of bone height after tooth removal? Does PRF improve how much of the socket fills with new bone?
Researchers will compare extraction sites treated with PRF to untreated sites in the same person to see if PRF helps preserve more bone.
Participants will:
Have two teeth removed on opposite sides of the mouth Receive PRF in one socket, while the other socket is left to heal naturally Undergo 3D X-ray scans (CBCT) right after extraction and again 3 months later
This study will help researchers understand if using PRF alone can improve healing and reduce bone loss after tooth extraction.
Zahedan University of Medical Sciences is the lead sponsor of 15 studies on the registry; 1 is open to participants now.
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Participants were eligible for inclusion if they met the following criteria:
No systemic conditions known to impair healing, including the following:
Exclusion Criteria:
Patients were excluded if they met any of the following conditions:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Each participant will have two symmetrical tooth extractions. One socket will be randomly assigned to receive platelet-rich fibrin (PRF), and the contralateral socket will serve as a control, healing naturally without any graft material. This split-mouth design allows each participant to act as their own control. Radiographic assessments using cone-beam computed tomography (CBCT) will be conducted at baseline and 3 months to measure bone height, ridge width, and socket fill.
Biological: Platelet-rich fibrin (PRF)
Each participant will have two symmetrical tooth extractions. One socket will be randomly assigned to receive platelet-rich fibrin (PRF), and the contralateral socket will serve as a control, healing naturally without any graft material. This split-mouth design allows each participant to act as their own control. Radiographic assessments using cone-beam computed tomography (CBCT) will be conducted at baseline and 3 months to measure bone height, ridge width, and socket fill.
Platelet-rich fibrin (PRF) is an autologous blood-derived material prepared by centrifuging the participant's venous blood without anticoagulants. The PRF clot is then compressed into a membrane and inserted into the extraction socket. It serves as a scaffold rich in platelets and growth factors to support bone regeneration and healing.
Change in Vertical Ridge Height from Baseline to 3 Months Post-Extraction as Measured by Cone-Beam Computed Tomography (CBCT)
Vertical ridge height was measured using cone-beam computed tomography (CBCT) at two time points: immediately after tooth extraction (baseline) and at 3 months post-extraction. Measurements were taken from the crest of the alveolar ridge to the apex of the extraction socket on both the buccal and lingual sides. The difference in ridge height between the two time points represents the amount of vertical bone loss. A smaller change indicates better preservation of ridge height. The measurements were performed by a blinded radiologist using standardized 1 mm slice thickness and reference lines drawn from the socket apex to the ridge crest.
Time frame: Immediately post-extraction (baseline) and at 3 months post-extraction
Change in Horizontal Ridge Width at 1 mm, 3 mm, and 5 mm Apical to the Crest from Baseline to 3 Months Post-Extraction Measured by CBCT
Horizontal ridge width was measured at 1 mm, 3 mm, and 5 mm below the lingual/palatal crest using cone-beam computed tomography (CBCT). The change in width between baseline and 3 months post-extraction was calculated. Smaller changes indicate better preservation of ridge width. Measurements were made using standardized reference lines and a slice thickness of 1 mm.
Time frame: Immediately post-extraction (baseline) and at 3 months post-extraction
Percentage of Socket Fill at 3 Months Post-Extraction as Measured by CBCT
The percentage of socket fill was determined using CBCT imaging at 3 months post-extraction. Socket fill refers to the amount of mineralized bone formation within the extraction site. A higher percentage indicates greater bone regeneration. A blinded radiologist performed all measurements using pre-defined reference points and standardized protocols.
Time frame: 3 months post-extraction
Plan to share: Yes — Individual de-identified participant data (IPD), study protocol, statistical analysis plan, informed consent form, and clinical study report will be made available to qualified researchers after study completion and publication of the main article. Access will be granted upon reasonable request through written communication with the corresponding author and will be limited to research purposes. Data will be available for at least five years following publication.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report
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This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: P-prf
Zahedan University of Medical Sciences