An interventional study of H1 receptor blockade: 540 mg (Allegra), H2 receptor blockade: 40 mg (Pepcid AC) in Prehypertension (elevated Blood Pressure) or Hypertension, sponsored by California Baptist University. Completed at 1 site in United States. Open to male participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-08.
Sponsored by California Baptist University · Not applicable, Interventional, and Basic science
It was hypothesized that aerobic exercise with blood flow restriction (BFR) induced post exercise hypotension (PEH), and the reduction in blood pressure (BP) was due to peripheral vasodilation via the histamine receptors. Ten male participants participated in this study. The participants were randomly assigned to walk for 10 minutes at 6.4 k/m, 0% grade with or without BFR after taking histamine receptor blockade. Following exercise, BP was measured at 10 min interval for 60 minutes. Heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure (MAP), and total peripheral resistance (TPR) were evaluated.
151 studies on the registry are indexed under Prehypertension; 22 are open to participants now.
This study's enrollment of 10 is below the median of 64 across 133 interventional studies indexed under Prehypertension.
Browse Prehypertension studies →California Baptist University is the lead sponsor of 8 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Genetic: H1 receptor blockade: 540 mg (Allegra), H2 receptor blockade: 40 mg (Pepcid AC)
Genetic: H1 receptor blockade: 540 mg (Allegra), H2 receptor blockade: 40 mg (Pepcid AC)
Subjects ingested fexofenadine (540 mg, tablet) at least 50 minutes before and famotidine (40 mg, tablet) 1 hour 50 minutes before the onset of each protocol because these dose of oral fexofenadine and famotidine reaches its peak concentration at around 1 h and 2 h, respectively
Post-exercise hypotension before and after the histamine blockade
Blood pressure change during 60 min (10 min interval) after BFR exercise
Time frame: 10 min, 20 min, 30 min, 40 min, 50 min, and 60 min post exercise
Plan to share: Undecided
No publications or documents are linked to this record.
Ran from Apr 2024 to primary completion in Aug 2024, 4 months.
Of 55 non-industry interventional studies with no phase under Prehypertension, half reached primary completion within 20 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 39. This study's 4 months is below that.
Counting every sponsor, half of 60 studies reached it within 20 months; a quarter within 11 and three quarters within 39.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.
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California Baptist University