An interventional study of Grape seed extract in Dietary Supplementation, sponsored by California Baptist University. Completed at 1 site in United States. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-07-14.
Sponsored by California Baptist University · Not applicable, Interventional, and Prevention
The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.
California Baptist University is the lead sponsor of 7 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Grape seed extract
Dietary Supplement: Grape seed extract
Placebo (starch)
Dietary Supplement: Grape seed extract
Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.
Systolic blood pressure (mmHg) by sphygmomanometer
Measured from the brachial artery
Time frame: 24 hours
Diastolic blood pressure (mmHg) by sphygmomanometer
Measured from the brachial artery
Time frame: 24 hours
Mean arterial pressure (mmHg)
calculated (MAP = (SBP-DBP)/3 + DBP
Time frame: 24 hours
Heart rate (bpm)
measured using Physio Flow (non-invasive device)
Time frame: 24 hours
Stroke volume (ml)
measured using Physio Flow (non-invasive device)
Time frame: 24 hours
Cardiac output (l/min)
calculated: HR (bpm) x SV (ml)
Time frame: 24 hours
Total peripheral resistance (mmHg/l/min)
calculated: MAP (mmHg) / CO (l/min)
Time frame: 24 hours
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2023. You cannot join it, but the record below documents what was studied.
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California Baptist University