An interventional study of Grape Seed Extract and Placebo in Prehypertension, sponsored by California Baptist University. Completed at 1 site in United States. Open to male participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-05-24.
Sponsored by California Baptist University · Not applicable, Interventional, and Basic science
This study aimed to assess the effect of the supplementation with grape seed extract (GSE) on blood pressure during static handgrip exercise and muscle metaboreflex in individuals with elevated and state 1 hypertension.
Muscle metatoreflex (MMR) has been known to play an important role in adjusting hemodynamic responses during exercise. The reflex increases sympathetic activity to heart and blood vessels to increase blood supply to contracting skeletal muscles. On the other hand, studies demonstrated that abnormal cardiovascular responses occurred by the overactive MMR in pathological conditions such as hypertension, diabetes, and congestive heart failure. Excessive blood pressure (BP) responses to exercise induce cardiovascular events such as stroke, heart attack, and coronary artery disease. Previously, a study found that dietary supplementation with grape seed extract (GSE) reduced BP response to dynamic exercise in individuals with elevated and stage 1 hypertension (ES1H) and associated with peripheral vasodilation. However, mechanisms underlying this phenomenon are not clear. Purpose: therefore, the purpose of this study is to investigate whether chronic dietary supplementation with GSE can decrease BP responses to exercise and this observation is associated with reduced MMR. Methods: 12 ES1H males were studied. Changes in cardiac output (Q), mean arterial pressure (MAP) and total peripheral resistance (TPR) were compared between the GSE and placebo supplementations during static handgrip exercise (SHE) and post exercise muscular ischemia (PEMI). Participants completed 3 min of SHE at 40% of MVC followed by 2 min of PEMI.
158 studies on the registry are indexed under Prehypertension; 21 are open to participants now.
This study's enrollment of 12 is below the median of 66 across 138 interventional studies indexed under Prehypertension.
Browse Prehypertension studies →California Baptist University is the lead sponsor of 8 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Participants received the supplement (600 mg, capsules) via cross-over design for 7 days
Dietary Supplement: Grape Seed Extract · Dietary Supplement: Placebo
Participants received the placebo (600 mg, capsules) via cross-over design for 7 days
Dietary Supplement: Grape Seed Extract · Dietary Supplement: Placebo
dietary supplements that rich in polyphenolic compounds
Starch
heart rate (bpm)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
Time frame: 5 minutes, 3 minutes, and 2 minutes, respectively.
stroke volume (ml)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
Time frame: 5 minutes, 3 minutes, and 2 minutes, respectively.
cardiac output (l/min)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
Time frame: 5 minutes, 3 minutes, and 2 minutes, respectively.
systolic blood pressure (mmHg)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
Time frame: 5 minutes, 3 minutes, and 2 minutes, respectively.
diastolic blood pressure (mmHg)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
Time frame: 5 minutes, 3 minutes, and 2 minutes, respectively.
total peripheral resistance (mmHg/l/min)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
Time frame: 5 minutes, 3 minutes, and 2 minutes, respectively.
Plan to share: No — This study needs the Institutional Research Board (IRB) and participant's approvals to share the data. Without the approval, the data collected from this study will not be shared.
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This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Grape Seed Extract
California Baptist University