An interventional study of Breakfast only and FAST in Osteopenia or Osteoporosis, sponsored by Sheffield Hallam University. Not yet recruiting. Open to male participants aged 24 Years to 32 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-08-13.
Sponsored by Sheffield Hallam University · Not applicable, Interventional, and Prevention
Osteoporosis is a major contributor to loss of independence due to bone fractures and resulting hospital treatments lead to significant morbidity. While pharmacological treatments can reduce consequences of osteoporosis, there is a pressing need for non-pharmacological interventions to improve bone health across the life-course and to reduce likelihood of age-related bone disease.
This study will allow us to determine whether synergistic potentiating effects on bone metabolism are observed in humans in relation to the timing of food ingestion and what recommendations can be made to people with respect to food ingestion and exercise to obtain the maximal bone benefits from aerobic exercise. Furthermore, if we can identify interventions that potentiate bone's response to aerobic exercise in younger adults, then such interventions may have the ability to maximise bone mass in younger adults so that with ageing, the additional bone mineral density and improved bone microarchitecture would extend the time before osteoporotic "fracture thresholds" are reached. Therefore, understanding the bone metabolic response to exercise following fasting and feeding in younger adults is important.
1,640 studies on the registry are indexed under Osteoporosis; 212 are open to participants now.
This study's planned enrollment of 16 is below the median of 95 across 1,133 interventional studies indexed under Osteoporosis.
Browse Osteoporosis studies →Sheffield Hallam University is the lead sponsor of 44 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Breakfast only without the exercise protocol
Other: Breakfast only
Participants will be exercised 90 minutes following a 12-hour overnight fast
Other: FAST
Participants will be exercised 90 minutes after a meal
Other: FED
Participants will attend a breakfast-only arm without the exercise protocol.
Participants will be exercised for 90 minutes following a 12-hour overnight fast
Participants will be exercised 90 minutes after a breakfast
C-terminal telopeptide of type-1 collagen (CTX-1)
The primary endpoint of this study is the change of the bone resorption biomarker C-terminal telopeptide of type-1 collagen (CTX-1) expression
Time frame: Between pre-exercise and 2 hours following the exercise timepoints
Procollagen type 1 N-terminal propeptide (P1NP)
The change of the bone formation biomarker procollagen type 1 N-terminal propeptide (P1NP) expression
Time frame: Between pre-exercise and 2 hours following the exercise timepoints
Cortisol
Markerof physiological and psychological stress is assessed and because of its promotion of bone resorption
Time frame: Between pre-exercise and 2 hours following the exercise timepoints
Insulin
The change of concentration in fasted and fed states is assessed
Time frame: Between pre-exercise and 2 hours following the exercise timepoints
Glucose
The change of concentration in fasted and fed states is assessed
Time frame: Between pre-exercise and 2 hours following the exercise timepoints
No study locations are listed for this record.
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This study is not yet recruiting, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.
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Sheffield Hallam University