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Active, not recruitingNCT06520761Updated Jul 25, 2024

The Effect of Injectable PRF Vs LLL on Orthodontic Tooth Movement

An interventional study of Injectable platelet rich fibrin and Low Level LASER in Rate of Canine Retraction and Root Resorption, sponsored by Faculty of Dental Medicine for Girls. Active, not recruiting at 1 site in Egypt. Open to female participants aged 18 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-25.

Sponsored by Faculty of Dental Medicine for Girls · Not applicable, Interventional, and Other

From the registry’s dates

  • Primary completion was expected by Dec 2024, 1 year 11 months ago, but the record still lists the study as active, not recruiting.
  • Registered 1 year 8 months after the study started (first participant enrolled Nov 2022, registered Jul 2024).
Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
18 Years to 25 Years
Sex
Female
01

Study summary

The purpose of the present study is to compare the effect of injectable platelet fibrin and Low Level LASER therapy on the rate of upper canine retraction, and on root resorption of the canine

Read the detailed description

the study involves two groups the first group received low level laser at the upper right canine, while the upper left canine act as a control. The second group received injectable platelet rich fibrin at the upper right canine, while the upper left canine act as a control. in each group we will compare rate of canine retraction between both sides, and amount of root resorption also we will compare both groups regarding rate of canine retraction and amount of root resorption

02

Conditions studied

  • Rate of Canine Retraction
  • Root Resorption

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03

In context

Root Resorption

43 studies on the registry are indexed under Root Resorption; 9 are open to participants now.

This study's enrollment of 20 is below the median of 29 across 36 interventional studies indexed under Root Resorption.

Browse Root Resorption studies →

Lead sponsor

Faculty of Dental Medicine for Girls is the lead sponsor of 54 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 25 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Patients with age 18 years or older.
  2. Presence of all permanent teeth except for the third molar.
  3. Presence of malocclusion requiring maxillary first premolar extraction such as (class II division 1 or bimaxillary dentoalveolar protrusion).

Exclusion criteria

Exclusion Criteria:

  1. Patient with a history of previous orthodontic treatment.
  2. Medical problems may interfere with orthodontic treatment.
  3. Bad oral hygiene.
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
20 participants (actual)

Study arms

  • Experimental
    injectable platelet rich fibrin

    blood sample is collected from the patient, centrifuged at 700rpm for 3 minutes then the resulted injectable platelet rich fibrin is injected around the upper right canine while the upper left canine act as a control

    Procedure: Injectable platelet rich fibrin

  • Experimental
    Low Level LASER

    low level laser from diode laser machine is applied around the upper right canine and the upper left canine acts as a control

    Device: Low Level LASER

Interventions

  • ProcedureInjectable platelet rich fibrin

    blood sample obtained from the participant, centrifuged at 700 rpm to produce injectable platelet rich fibrin, this will be injected around the upper canine

  • DeviceLow Level LASER

    Diode LASER device is used to apply Low Level LASER around the upper canine

06

What researchers measure

Primary outcomes

  1. Rate of canine retraction

    measure the rate of distal movement of the upper canine

    Time frame: 4 month

Secondary outcomes

  1. Root resorption of upper canine

    measure root resorption of upper canine

    Time frame: 4 month

07

Study locations

1 site
08

References and documents

Publications

  • Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement : A randomized split-mouth-controlled trial. J Orofac Orthop. 2021 Jul;82(4):268-277. doi: 10.1007/s00056-020-00275-x. Epub 2021 Jan 22. PubMed 33481053 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 25, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06520761
Lead sponsor
Faculty of Dental Medicine for Girls
Responsible party
Sponsor
First posted
Jul 25, 2024
Start date
Nov 1, 2022
Primary completion
Dec 1, 2024 (estimated)
Completion
Dec 1, 2024 (estimated)
Last update
Jul 25, 2024

Study contacts

Samir A Ebrahim, Professor
principal investigator · Head of orthodontic department at faculty of Dental Medicine for Girls Al-Azhar university

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.

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