An interventional study of Nano Silver Fluoride and Bioactive Glass Gel in Radiation Caries, sponsored by Faculty of Dental Medicine for Girls. Recruiting at 1 site in Egypt. Open to participants aged 6 Years to 10 Years. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by Faculty of Dental Medicine for Girls · Not applicable, Interventional, and Prevention
This study aims to evaluate and compare the remineralizing and antimicrobial effects of nano silver fluoride and bioactive glass gel on primary teeth exposed to therapeutic radiation. The study includes both in vitro and in vivo components. The clinical component will include 30 pediatric patients aged 6-10 years undergoing therapeutic head and neck radiotherapy. Participants will be randomly allocated into two groups to receive either nano silver fluoride or bioactive glass gel. The effects of the interventions will be evaluated using salivary pH and bacterial count measurements. The laboratory component will evaluate changes in irradiated primary tooth enamel, including surface morphology, mineral content, and microhardness.
The study consists of in vitro and in vivo components designed to evaluate the effects of therapeutic radiation on primary teeth and to compare the effects of nano silver fluoride and bioactive glass gel.
For the in vitro component, 12 sound extracted primary molars will be sectioned mesiodistally to obtain 24 enamel specimens. The specimens will be exposed to therapeutic radiation and randomly assigned to two groups. One group will receive nano silver fluoride solution, while the other will receive bioactive glass gel. Enamel specimens will be evaluated at baseline, after radiation exposure, and after application of the assigned material. Assessments will include scanning electron microscopy for surface morphology, energy-dispersive X-ray spectroscopy for mineral analysis, and Vickers microhardness testing.
For the in vivo component, 30 pediatric patients undergoing therapeutic head and neck radiotherapy will be randomly allocated into two groups of 15 participants. The first group will receive a single application of nano silver fluoride solution for one minute. The second group will use bioactive glass gel once daily for one minute for seven days. Clinical assessment will include measurement of salivary pH and bacterial counts before and after application of the assigned intervention.
Faculty of Dental Medicine for Girls is the lead sponsor of 54 studies on the registry; 6 are open to participants now.
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Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive a single application of nano silver fluoride solution for 1 minute.
Other: Nano Silver Fluoride
Participants will receive bioactive glass gel once daily for 1 minute for 7 days
Other: Bioactive Glass Gel
Nano silver fluoride solution will be topically applied once for 1 minute
Also known as: nano silver flouride
Bioactive glass gel will be topically applied once daily for 1 minute for 7 consecutive days
Change in Salivary Bacterial Count
Salivary bacterial count will be measured to evaluate the antimicrobial effect of nano silver fluoride compared with bioactive glass gel.
Time frame: Baseline and 1 week after intervention
Change in Salivary pH
Salivary pH will be measured before and after the intervention to evaluate changes following treatment with nano silver fluoride or bioactive glass gel
Time frame: Baseline and 1 week after intervention
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Faculty of Dental Medicine for Girls