An interventional study of Nestle Isocal and Nestle Boost Optimum in Colorectal Cancer, Ileus Postoperative and Flatus, sponsored by National University Hospital, Singapore. Recruiting at 1 site in Singapore. Open to participants aged 21 Years to 99 Years. Per ClinicalTrials.gov, last updated 2024-06-13.
Sponsored by National University Hospital, Singapore · Not applicable, Interventional, and Treatment
There is pre-existing evidence that probiotics could be useful in the improvement of ileus rates. One metaanalysis of 30 studies demonstrated a reduction in the prevalence of post-operative ileus as determined by time to flatus, time to defecation, as well as postoperative abdominal distension (PMID:37373843). More broadly in gastrointestinal surgery, a meta-analysis of 21 randomised controlled trials similarly affirmed the speedier recovery of gastrointestinal function after surgery when probiotics were administered (PMID: 35231076). In spite of these advantages, the routine use of probiotics perioperatively for colorectal cancer surgery is not performed in Singapore. We therefore seek to perform a trial to investigate whether probiotic administration perioperatively may reduce post operative ileus rates.
5,599 studies on the registry are indexed under Colorectal Neoplasms; 1,459 are open to participants now.
This study's planned enrollment of 162 is above the median of 77 across 4,123 interventional studies indexed under Colorectal Neoplasms.
Browse Colorectal Neoplasms studies →National University Hospital, Singapore is the lead sponsor of 444 studies on the registry; 96 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Control arm with no nutritional supplementation
Control arm with nutritional supplementation but without probiotics
Dietary Supplement: Nestle Isocal
Nutritional supplementation with probiotics
Dietary Supplement: Nestle Boost Optimum
Nestle Isocal
Nestle Boost Optimum
Time to bowel movement
This records the number of days from the day of surgery before the first bowel movement was experienced by the patient.
Time frame: 0 - 14 days
Time to flatus
This records the number of days from the day of surgery before the first flatus was experienced by the patient.
Time frame: 0 - 14 days
Adverse events
Any adverse events related to the intervention. This comprises predominantly gastrointestinal related complications
Time frame: From commencement of the intervention to 30 days after surgery
Infective complications
Any infective complications which may occur in the postoperative period.
Time frame: From date of surgery to 30 days after surgery
Length of hospital stay
This records the number of days following surgery before the patient is discharged.
Time frame: 0 - 14 days
Plan to share: No — Individual participant data will not be shared.
No publications or documents are linked to this record.
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National University Hospital, Singapore