An observational study in Herpes Zoster, sponsored by Huazhong University of Science and Technology. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-08-26.
Sponsored by Huazhong University of Science and Technology · Observational
The goal of this observational study is to explore risk factors of anxiety and depression in patients with herpes zoster neuralgia, and the changes of certain serum biomarkers and functional brain magnetic resonance images of these patients.
Patients with herpes zoster neuralgia will be recruited and take Hospital anxiety depression rating scale (Hospital anxiety and 'scale, HADS) evaluation. According to the HADS Scores, patients will be divided into depression group and no depression, or anxiety group and no anxiety group. The clinical data the of two groups will be collected and statistically analyzed to explore the risk factors of anxiety and depression, including the changes of serum biomarkers and functional brain magnetic resonance imaging in patients with herpes zoster neuralgia accompanying anxiety or depression.
370 studies on the registry are indexed under Herpes Zoster; 63 are open to participants now.
This study's planned enrollment of 600 is above the median of 355 across 51 observational studies indexed under Herpes Zoster.
Browse Herpes Zoster studies →Huazhong University of Science and Technology is the lead sponsor of 246 studies on the registry; 62 are open to participants now.
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This study will be conducted in patients who are diagnosed as herpes zoster neuralgia
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients in this group suffered from herpes zoster neuralgia and had a score more than or equal to 8 for Hospital Anxiety and Depression Scale- Anxiety questionnaire.
Diagnostic Test: Hospital Anxiety and Depression Scale
Patients in this group suffered from herpes zoster neuralgia and had a score less than 8 for Hospital Anxiety and Depression Scale- Anxiety questionnaire.
Diagnostic Test: Hospital Anxiety and Depression Scale
Patients in this group suffered from herpes zoster neuralgia and had a score more than or equal to 8 for Hospital Anxiety and Depression Scale- Depression questionnaire.
Diagnostic Test: Hospital Anxiety and Depression Scale
Patients in this group suffered from herpes zoster neuralgia and had a score less than 8 for Hospital Anxiety and Depression Scale- Depression questionnaire.
Diagnostic Test: Hospital Anxiety and Depression Scale
Hospital Anxiety and Depression Scale questionnaire is used to test patients for anxiety and depression.
HADS score
Enrolled patients will be first evaluated by Hospital Anxiety and Depression Scare questionaire and according to the HADS score, patients will be divided to group with anxiety/depression and group without anxiety/depression.
Time frame: during hospital stay, average of 1 week
Interleukin (IL）-1β plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-1β （pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
IL-2 receptor plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-2 （u/ml）will be tested.
Time frame: during hospital stay, average of 1 week
IL-6 plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-6 （pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
IL-8 plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-8 （pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
IL-10 plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-10 （pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
Interferon(INF)-α plasma level
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines INF-α （pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
Brain-derived neurotrophic factor (BDNF) plasma level
Blood sample will be obtained from enrolled patients and the plasma level of BDNF（pg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
C-reactive protein (CRP) plasma level
Blood sample will be obtained from enrolled patients and the plasma level of CRP（mg/ml）will be tested.
Time frame: during hospital stay, average of 1 week
Area under curve (AUC) of topological metrics of functional brain magnetic resonance imaging
Functional brain magnetic resonance imaging will be performed in patients with anxiety or depression, and area under curve (AUC) of topological metrics including Eglob,Eloc,Cp,Lp,γ,λ and σ will be calculated and analyzed.
Time frame: during hospital stay, average of 1 week
Plan to share: No — no plan to make individual participant data (IPD) available to other researchers
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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