An observational study in Sepsis Syndrome, Septic Shock and Sepsis, sponsored by Assistance Publique Hopitaux De Marseille. Recruiting at 1 site in France. Open to male participants aged 45 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-02-12.
Sponsored by Assistance Publique Hopitaux De Marseille · Observational
Sepsis is a multifactorial syndrome characterized by a dynamic course and a clinical outcome dependent on several factors, and responsible for one in five deaths worldwide. The aim of this trial is to identify new prognostic markers for the progression of sepsis to septic shock, by comparing epigenetic markers between patients who have or have not developed severe forms of sepsis.
The main objective of this preliminary study is to identify prognostic markers for the progression of sepsis to septic shock, i.e. to compare targeted markers between subjects with sepsis who progress to septic shock versus subjects with sepsis who do not progress to septic shock.
180 studies on the registry are indexed under Systemic Inflammatory Response Syndrome; 24 are open to participants now.
This study's planned enrollment of 25 is below the median of 134 across 88 observational studies indexed under Systemic Inflammatory Response Syndrome.
Browse Systemic Inflammatory Response Syndrome studies →Assistance Publique Hopitaux De Marseille is the lead sponsor of 686 studies on the registry; 148 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Male patients admitted to critical care for sepsis after thoracic or chest surgery.
Exclusion Criteria:
Patients with sepsis admitted to intensive care who developed septic shock.
Other: blood sampling
Patients with sepsis admitted to critical care with a favorable outcome (no septic shock)
Other: blood sampling
Blood sampling (6ml) on admission and a second on discharge from intensive care.
Identify prognostic markers for the progression of sepsis to septic shock
Compare targeted markers between subjects with sepsis progressing to septic shock versus subjects with sepsis not progressing to septic shock.
Time frame: 18 months
Epigenetic markers comparaison
Epigenetic markers and associated candidate genes identified in PBMC at the time of sepsis between the group of subjects progressing to septic shock and the group of subjects not progressing to septic shock.
Time frame: 18 months
Differentials in epigenetic marks and associated candidate genes
Compare differentials in epigenetic marks and associated candidate genes (sepsis, second sampling) between the group of subjects progressing to septic shock and the group of subjects not progressing to septic shock
Time frame: 18 months
Epigenetic marks and associated candidate genes identified in PBMC
In both groups, compare the epigenetic marks and associated candidate genes identified in PBMC during sepsis with those identified in PBMC collected at the time of septic shock or discharge from critical care.
Time frame: 18 months
Plan to share: No
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Systemic Inflammatory Response Syndrome→
Assistance Publique Hopitaux De Marseille