An observational study in Respiratory Distress Syndrome, Adult, sponsored by Başakşehir Çam & Sakura City Hospital. Completed at 1 site in Turkey. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-05-28.
Sponsored by Başakşehir Çam & Sakura City Hospital · Observational
This study aims to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.
Recent studies have shown that mechanical power (MP) values below 17 J/min and driving pressure (DP) values below 15 cmH2O reduce intensive care unit (ICU) mortality. Asar et al. have introduced six new oxygenation indices utilizing MP and DP instead of Pmean (OSI-MPtot, OI-MPtot, OSI-ΔPinsp, OI-ΔPinsp, OSI-MPdyn, OI-MPdyn). They compared the predictive abilities of these new indices for ICU mortality in Covid-ARDS (C-ARDS) patients with conventional oxygenation indices (P/F, SpO2/FiO2, OI, OSI, PaO2/(FiO2xPEEP), and SpO2/FiO2xPEEP). OI-ΔPinsp, OSI-ΔPinsp, and OSI-MPdyn indices exhibited the highest predictive power for ICU mortality. However, cut-off values for the diagnosis and severity determination (mild, moderate, and severe) of ARDS patients have not been investigated.
In this study, our objective is to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.
1,597 studies on the registry are indexed under Respiratory Distress Syndrome; 312 are open to participants now.
This study's enrollment of 2,000 is above the median of 100 across 540 observational studies indexed under Respiratory Distress Syndrome.
Browse Respiratory Distress Syndrome studies →Başakşehir Çam & Sakura City Hospital is the lead sponsor of 105 studies on the registry; 36 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients admitted to the intensive care unit of Istanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital with a preliminary diagnosis of ARDS/C-ARDS between June 01, 2012, and February 01, 2024
Exclusion Criteria:
The oxygenation indexes of the patients will be measured and the effectiveness of these indexes in diagnosing ARDS will be compared.
Oxygenation indices
It was aimed to compare the oxygenation indexes of the patients. It will be examined which of these indices is more effective in diagnosing ARDS.
Time frame: During 28 days in the intensive care unit
Other parameters
It was aimed to compare the sequential organ failure assessment scores of the patients. Score ranges from 0 (best outcome) to 24 (worst outcome) points.
Time frame: During 28 days in the intensive care unit
acute physiology and chronic health evaluation-II
It was aimed to compare the acute physiology and chronic health evaluation-II scores of the patients. Score ranges from 0 (best outcome) to 71 (worst outcome) points.
Time frame: During 28 days in the intensive care unit
Charlson comorbidity index scores
It was aimed to compare the Charlson comorbidity index scores of the patients. Based on the Charlson comorbidity index score, the severity of comorbidity was categorized into three grades: mild, with Charlson comorbidity index scores of 1-2; moderate, with Charlson comorbidity index scores of 3-4; and severe, with Charlson comorbidity index scores ≥5.
Time frame: During 28 days in the intensive care unit
Other parameters
It was aimed to compare the Charlson comorbidity index of the patients.
Time frame: During 28 days in the intensive care unit
arterial blood gas parameters
It was aimed to compare the pH of the patients.
Time frame: During 28 days in the intensive care unit
arterial blood gas parameters
It was aimed to compare the base excess of the patients.
Time frame: During 28 days in the intensive care unit
arterial blood gas parameters
It was aimed to compare the lactate of the patients.
Time frame: During 28 days in the intensive care unit
arterial blood gas parameters
It was aimed to compare the partial oxygen pressure of the patients.
Time frame: During 28 days in the intensive care unit
Plan to share: No
This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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Respiratory Distress Syndrome→
Başakşehir Çam & Sakura City Hospital