An observational study in Weaning Failure, Central Respiratory Depression and Diaphragm Injury, sponsored by The First Affiliated Hospital of Guangzhou Medical University. Recruiting at 1 site in China. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-09.
Sponsored by The First Affiliated Hospital of Guangzhou Medical University · Observational
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT).
The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .
This observational study mainly include participants who had invasive mechanical ventilation for ≥48 h and are assessed to be ready for the SBT trial.The SBT approach is based on the low-level pressure support mode.
Prior to the SBT trial, baseline demographic and physiologic data of the participants will be collected, and the participants will be divided into two groups based on the results of the SBT trial: successful and unsuccessful, and the physiologic changes during the SBT trial will be compared between the two groups, respectively.
1,650 studies on the registry are indexed under Respiratory Insufficiency; 296 are open to participants now.
This study's planned enrollment of 30 is below the median of 100 across 545 observational studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →The First Affiliated Hospital of Guangzhou Medical University is the lead sponsor of 158 studies on the registry; 65 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients undergoing weaning from mechanical ventilation；Hemodynamic stability
Exclusion Criteria:
Patient passed SBT test with no need to receive invasive mechanical ventilation 48 hours after extubation
Diagnostic Test: Monitoring of respiratory mechanics parameters
Patient failed SBT test or need to receive invasive mechanical ventilation 48 hours after extubation
Diagnostic Test: Monitoring of respiratory mechanics parameters
Physiologic recording instrumentation measure maximal transdiaphragmatic pressure，twitch diaphragmatic pressure and maximal diaphragmatic electromyography
weaning success
passed SBT trial and weaning from mechanical ventilation success with no need of reintubation
Time frame: Day 2
Plan to share: Undecided
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The First Affiliated Hospital of Guangzhou Medical University