An interventional study of group N used traditional nasal cannula for oxygen inhalation and Group HFNC used nasal high-flow oxygen inhalation. in COPD, sponsored by The First Affiliated Hospital of Guangzhou Medical University. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-30.
Sponsored by The First Affiliated Hospital of Guangzhou Medical University · Not applicable, Interventional, and Treatment
Bronchoscopy diagnosis and treatment is highly irritating, and the effect of local topical anesthesia is poor; the airway is shared; and COPD patients have low oxygen reserves due to impaired lung function. At present, clinical anesthesia generally uses nasal cannula for oxygen inhalation. If the anesthesia is too shallow, it may cause airway spasm, and if the anesthesia is too deep, it will inhibit breathing and lead to hypoxia. Hypoxemia has been reported in 66% of COPD patients undergoing sedation for bronchoscopy. Therefore, solving hypoxia is the biggest problem in anesthesia for bronchoscopy diagnosis and treatment.
Bronchoscopy diagnosis and treatment is highly irritating, and local topical anesthesia has poor effect; deep sedation or intravenous anesthesia based on topical anesthesia is currently recommended; COPD patients have impaired lung function, and bronchoscopy diagnosis and treatment is accompanied by significant peri-anesthetic risks of hypoxemia. COPD patients are prone to hypoxemia due to the shared airway and sedative and analgesic drugs used to suppress breathing during bronchoscopy diagnosis and treatment. Therefore, solving hypoxia is the biggest problem for COPD patients during anesthesia during bronchoscopy. In recent years, studies have found that high-flow nasal oxygen therapy (HFNC) can significantly reduce the incidence of hypoxemia during anesthesia during bronchoscopy. However, very few studies have performed HFNC on patients with COPD.
Exclusion Criteria:
Group N used traditional nasal cannula to inhale oxygen during anesthesia.
Other: group N used traditional nasal cannula for oxygen inhalation
During anesthesia, the HFNC group used nasal high-flow oxygen inhalation
Other: Group HFNC used nasal high-flow oxygen inhalation.
1000 COPD patients who underwent bronchoscopy were randomly divided into 2 groups in a 1:1 ratio.Nasal high-flow oxygen therapy group（group N） and nasal cannula oxygen inhalation group(group HFNC）.The N group used traditional nasal cannula for oxygen inhalation, and the HFNC group used nasal high-flow oxygen inhalation.
1000 COPD patients who underwent bronchoscopy were randomly divided into 2 groups in a 1:1 ratio.Nasal high-flow oxygen therapy group（group N） and nasal cannula oxygen inhalation group(group HFNC）.The N group used traditional nasal cannula for oxygen inhalation, and the HFNC group used nasal high-flow oxygen inhalation.
pulse oximetry
Blood oxygen saturation during anesthesia, record the duration and number of times below 90%
Time frame: The entire anesthesia period during bronchoscopy
No study locations are listed for this record.
Plan to share: Yes — Upon completion of the study, de-identified individual participant data (IPD) and relevant supporting documents (e.g., study protocol, statistical analysis plan) will be shared upon reasonable request with researchers who provide a methodologically sound research proposal. Data will be made available starting 6 months after publication of the primary results and will remain available for 5 years. Requests must be submitted via \[designated email or website\], and a data use agreement must be signed.
No publications or documents are linked to this record.
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Pulmonary Disease, Chronic Obstructive→
The First Affiliated Hospital of Guangzhou Medical University