An observational study in Nomogram, Prediction Model and Type A Aortic Dissection, sponsored by Wuhan Union Hospital, China. Completed at 1 site in China. Open to participants aged 19 Years to 90 Years. Per ClinicalTrials.gov, last updated 2024-05-16.
Sponsored by Wuhan Union Hospital, China · Observational
Reintubation is an adverse postoperative complication in patients with Type A aortic dissection (AAD) that correlates to poor outcomes. This study aims to analyze the risk factors associated with reintubation and to create a fully automated score model to predict the incidence of reintubation. A total of 861 patients diagnosed with AAD and undergoing surgical procedures in a single institution between January 2018 and October 2023 were selected in wuhan Union Hospital. Preoperative and postoperative informmation was used for seeking risk factors and build prediction model for postoperative reintubation. Finally, 5 risk factors wasidentified and a nomogram was established for predicting postoperative reintubation in patients with AAD.
386 studies on the registry are indexed under Aortic Dissection; 117 are open to participants now.
This study's enrollment of 861 is above the median of 183 across 180 observational studies indexed under Aortic Dissection.
Browse Aortic Dissection studies →Wuhan Union Hospital, China is the lead sponsor of 230 studies on the registry; 104 are open to participants now.
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A total of 892 patients with AAD who underwent open surgery at Wuhan Union Hospital between January 2018 and October 2023 were enrolled using a convenient sampling method.
(1) patients diagnosed with AAD admitted for open surgery; (2) aged 18 years or older.
Exclusion Criteria:
(1) patients deceased during or within 24 hours after surgery; (2) patients with preoperative intubation.
To determine potential predictive factors, the training group was subjected to LASSO regression analysis, which effectively eliminated several irrelevant or multicollinearity independent variables to reduce high-dimensional data.Seven models were initially constructed in the training group: multivariable logistics regression (MLR), decision-tree modeling, random forest, XGBoost, Support Vector Machines, k-nearest neighbors, and LightGBM.
Procedure: Type A aortic dissection surgery
Testing group was used to examine the performance of the seven prediction models, including discrimination and calibration performance. Finally, the model with best discrimination and calibration performance was used to construct nomogram for predicting reintubation.
Procedure: Type A aortic dissection surgery
Patients with type A aortic dissection undergone surgery.
postoperative reintubation
reintubation incidence in patients with type A aortic dissection undergoing surgery
Time frame: 3 month
Plan to share: No
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This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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Wuhan Union Hospital, China