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Not yet recruitingNCT06402656Updated Jul 31, 2024

Comparison of Customized and Standard Facemasks for Early Treatment of Class III Malocclusion

An interventional study of Customized facemask and Standard facemask in Malocclusion, Angle Class III and Extraoral Traction Appliances, sponsored by Azienda Ospedaliero-Universitaria Careggi. Not yet recruiting. Open to participants aged 5 Years to 12 Years. Per ClinicalTrials.gov, last updated 2024-07-31.

Sponsored by Azienda Ospedaliero-Universitaria Careggi · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
24
Allocation
Randomized
Ages
5 Years to 12 Years
Sex
All
01

Study summary

The aim of the study is to compare a customized facemask for the treatment of Class III malocclusion in the prepubertal growing patient (patients between the ages of 5 and 12 years) versus a standard commercial facemask. Specifically, preference, pain, difficulty in sleeping, time of use, and possible complications for the two types of facemasks will be analyzed.

This is a single-center, national, controlled, superiority, randomized, crossover, open-label study.

Each patient will be treated with both the customized facemask and the standard commercial facemask. Each patient will wear one type of facemask for 2 months and the other type of facemask for the next 2 months. After 2 weeks and at the end of therapy with each of the facemask types, the patient, with the possible help of the parents, will have to answer a questionnaire about pain and difficulty sleeping and report any complications. In addition, after completing both phases (fourth month), the patient should indicate a preference for one of the two types of mask with which to complete therapy for an additional 6 months.

02

Conditions studied

  • Malocclusion, Angle Class III
  • Extraoral Traction Appliances
03

Who can participate

Ages eligible
5 Years to 12 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age between 5 and 12 years;
  • Class III malocclusion, for which early orthopedic treatment with rapid maxillary expander and facemask is indicated.
  • signing of informed consent

Exclusion criteria

Exclusion Criteria:

  • Cleft lip and/or palate.
  • Craniofacial syndromes.
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
24 participants (estimated)

Study arms

  • Experimental
    Customized facemask

    Device: Customized facemask

  • Active comparator
    Standard facemask

    Device: Standard facemask

Interventions

  • DeviceCustomized facemask

    The customized face mask will be fabricated from a 3D digital image of the patient's face obtained by means of a 3D scanner. Such a scanner consists of 6 digital SLR cameras and software capable of processing a 3-D image of the patient's face exportable as an stl file.

  • DeviceStandard facemask

    The standard facemask is the commercially available Petit standard facemask

05

What researchers measure

Primary outcomes

  1. Questionnaire on the preference of the patient for one of the two types of face masks

    The primary endpoint is a questionnaire on the preference between the two types of face masks at the end of the second phase of therapy (4 months after delivery of the first face mask)

    Time frame: 4 months

Secondary outcomes

  1. Pain reported by patients

    Pain measured through Visual Analogue Scale with minimum value of 0 and maximum value of 10. Higher scores mean worse pain.

    Time frame: At 2 weeks and at 2 months after delivery of each of the 2 face masks

  2. Difficulty in sleeping reported by patients

    Difficulty in sleeping measured through VAS Visual Analogue Scale with minimum value of 0 and maximum value of 10. Higher scores mean more difficulty in sleeping.

    Time frame: At 2 weeks and at 2 months after delivery of each of the 2 face masks

  3. Number of complications

    Number of complications

    Time frame: At 2 weeks and at 2 months after delivery of each of the 2 face masks

  4. Total time wear

    Total time wear measured with a thermosensor (Theramon)

    Time frame: At 2 months after delivery of each of the 2 face masks

06

Study locations

No study locations are listed for this record.

07

References and documents

Individual participant data

Plan to share: Undecided — IPD will be shared on appropriate request

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT06402656
Lead sponsor
Azienda Ospedaliero-Universitaria Careggi
Responsible party
Sponsor
First posted
May 7, 2024
Start date
Sep 1, 2024 (estimated)
Primary completion
Jan 1, 2025 (estimated)
Completion
Jan 1, 2026 (estimated)
Last update
Jul 31, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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