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CompletedNCT06384638Updated Apr 25, 2024

Coconut Oil in Treatment of Periodontitis

A Phase 1 interventional study of topical application of coconut oil and scaling and debridement in Periodontal Diseases, sponsored by Misr University for Science and Technology. Completed at 1 site in Egypt. Open to participants aged 35 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-25.

Sponsored by Misr University for Science and Technology · Phase 1, Interventional, and Treatment

From the registry’s dates

  • Registered 2 years 2 months after the study started (first participant enrolled Feb 2022, registered Apr 2024).
Phase
Phase 1
Study type
Interventional
Enrollment
34
Allocation
Randomized
Ages
35 Years to 60 Years
Sex
All
01

Study summary

Virgin Coconut Oil (VCO) is a vegetable oil extracted from coconut fleshcontains unsaturated fatty acids in the form of oleic acid and linoleic acid and flavonoids which function as anti-inflammatory. Periodontitis is an inflammatory disease of the periodontal tissues with a high prevalence worldwide. The main etiology of plaque periodontitis is biofilm containing colonies of pathogenic microorganisms. The aim of the study is to evaluate and compare the effect of scaling and root debridement alone versus the use of topically applied coconut oil as adjunctive to scaling and root debridement in treatment of Stage II and III Grade B periodontitis.

02

Conditions studied

  • Periodontal Diseases

Keywords

  • Periodontitis
  • coconut oil
  • scaling and debridement
03

In context

Periodontitis

1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.

This study's enrollment of 34 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.

Browse Periodontitis studies →

Lead sponsor

Misr University for Science and Technology is the lead sponsor of 34 studies on the registry; 12 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
35 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • patients age group >35 years without ant systemic disease
  • Willing to take part in the study. Patients with more than 16 natural teeth and have test teeth with both mesial and distal neighboring teeth with periodontitis with clinical attachment loss >3 mm and radiographic percentage of bone loss/age ranged between 0.25 to 1.
  • Patients with no history of allergies to coconut

Exclusion criteria

Exclusion Criteria:

  • smokers
  • pregnant
  • lactating women
  • Teeth with both endodontic-periodontal lesion.
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Care provider, Outcomes assessor)
Enrollment
34 participants (actual)

Study arms

  • Active comparator
    interventional

    coconut oil as topical application as adjunctive to scaling and root debridement

    Biological: topical application of coconut oil · Other: scaling and debridement

  • Active comparator
    control

    scaling and root debridement

    Other: scaling and debridement

Interventions

  • Biologicaltopical application of coconut oil

    topical application of coconut oil

  • Otherscaling and debridement

    scaling and debridement

06

What researchers measure

Primary outcomes

  1. clinical parameters

    clinical attachment loss

    Time frame: 3 months

  2. clinical parameters

    Probing depth

    Time frame: 3 months

Secondary outcomes

  1. Biological parameters

    Tumor necrosis factor alpha (TNF- α) levels by using ELISA.

    Time frame: 3 months

07

Study locations

1 site
  • Faculty of dentistry at MUST
    Giza, 02, Egypt
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 25, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06384638
Lead sponsor
Misr University for Science and Technology
Responsible party
Radwa Elsherif (lecturer of oral medicine, periodontology and oral diagnosis at Misr University for science and technology, Misr University for Science and Technology) — Principal investigator
First posted
Apr 25, 2024
Start date
Feb 15, 2022
Primary completion
Jan 16, 2024
Completion
Feb 9, 2024
Last update
Apr 25, 2024

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.

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