A Phase 2 interventional study of Polydeoxyribonucleotide and Fractional CO2 laser assisted PDT in Facial Scarring, sponsored by Misr University for Science and Technology. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-03-16.
Sponsored by Misr University for Science and Technology · Phase 2, Interventional, and Treatment
Facial scars are frequently deemed unpleasant and can profoundly impact a patient's psychological health. This study compares the effectiveness, safety, and capacity to speed up scar healing in the maxillofacial region between fractional carbon dioxide (CO₂) laser therapy alone and polydeoxyribonucleotide (PDRN) combined with CO₂ laser therapy.
Misr University for Science and Technology is the lead sponsor of 38 studies on the registry; 15 are open to participants now.
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Exclusion Criteria:
Medication use that could affect wound healing or inflammation, such as:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
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Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
includes patients who will be enrolled for PDRN injection into the surgical scar
Drug: Polydeoxyribonucleotide · Device: Fractional CO2 laser assisted PDT
includes patients who will be enrolled for placebo saline injection into the surgical scar
Device: Fractional CO2 laser assisted PDT
intralesional PDRN injections
Fractional carbon dioxide (CO₂) laser therapy for facial scars
Also known as: co2 laser
Vancouver Scar Scale
The study used the standard Vancouver Scar Scale, which evaluates four characteristics of scars: Total Score Range: 0 (normal skin) to 13 (severe hypertrophic scar)
Time frame: 4 months
Plan to share: Undecided
Started Mar 2026 (actual). Primary completion is estimated for Jul 2026, 4 months after the start.
How these figures are worked out, and which studies are left out of them.
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Studies of the drug tested here: Polydeoxyribonucleotides
Misr University for Science and Technology