An observational study in Anxiety Disorders, Obsessive-Compulsive Disorder and Post-traumatic Stress Disorder, sponsored by South London and Maudsley NHS Foundation Trust. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-04-17.
Sponsored by South London and Maudsley NHS Foundation Trust · Observational
Among 231 studies in Anxiety Disorders with a site in United Kingdom — 37 open to participants now, 38 under way, none of them phase 3. Anxiety Disorders · United Kingdom.
Among the 231 studies in Anxiety Disorders with a site in United Kingdom, this one is the 11th largest by enrollment of the 47 observational ones, is one of 14 that started in 2022, is one of 47 observational ones, and was the 194th registered.
7,201 studies on the registry are indexed under Anxiety Disorders; 1,682 are open to participants now.
This study's enrollment of 320 is above the median of 168 across 977 observational studies indexed under Anxiety Disorders.
Browse Anxiety Disorders studies →37 of the 231 studies in Anxiety Disorders with a site in United Kingdom are open now, in 7 countries. Each count lists the studies.
Of the 943 Anxiety Disorders studies recruiting now, 416 (44%) set no upper age limit and 460 (49%) stop at 75 or younger; 232 take children under 18; 316 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →231 studies; the count open now beside each. This study's row is marked.
First in 2001; this study’s year is marked. 14 started in 2022.
Median enrollment 60 across the 183 interventional studies, 150 across the 47 observational. Of the 157 that completed or were terminated, 17 (11%) have results posted.
25 of 231 have an industry lead sponsor. The 10 most frequent:
South London and Maudsley NHS Foundation Trust is the lead sponsor of 11 studies on the registry; 1 is open to participants now.
South London and Maudsley NHS Foundation Trust has 2 studies filed under Anxiety Disorders — fewer than ten, so there is no comparison to draw.
7 of the studies in Anxiety Disorders with a site in United Kingdom that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07872670NHS Highland Research, Development and Innovation OrganisationVirtual Reality Therapy to Improve Arthroplasty Outcomes | 2026-12-01 |
| NCT06604104University of EdinburghVisual Frailty in Ageing | 2027-01-11 |
| NCT07466446University of EdinburghPost Intensive Care Accelerometery to Study and Support Recovery Outcomes | 2027-02-01 |
| NCT07135232Leeds Beckett UniversityThe Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health. | 2027-03-01 |
| NCT07752342NovonesisExploring Wellbeing Outcomes in Adolescents Using Bifidobacterium Longum, 1714™ | 2027-04 |
Among the 231 studies in Anxiety Disorders with a site in United Kingdom, from their registry updates:
The goal of this observational study is to learn about the role of repetitive negative thinking (measured by the RTQ) in adult populations from an anxiety disorders and trauma clinic.
The main questions it aims to answer are:
Researchers may also compare clients with different disorders to see the accuracy the RTQ can predict treatment outcomes for each disorder.
We are looking to examine how repetitive negative thinking (RNT; i.e. rumination and worry), measured by the repetitive thinking questionnaire (RTQ), affects the outcomes of Cognitive Behavioural Therapy (CBT) for anxiety and trauma disorders. Our study will involve looking over data collected from clients who completed treatment at the Centre for Anxiety Disorders and Trauma (CADAT) from 01/01/2022 to 31/03/2024, we will look at data from before they started treatment, whilst in treatment and once they completed treatment. This is an important issue to address as there is little guidance within existing CBT protocols on to how to identify and target RNT during treatment. Evidence also suggests that not only does RNT maintain anxiety disorders, but it can also interfere with therapy outcome. Research has found that patients receiving CBT for PTSD who displayed high-levels of rumination within their early CBT sessions had poorer outcomes in therapy. Our aim is to formally analyse the relationship between scores on the RTQ and both symptom severity and CBT treatment outcome for anxiety disorders. This would help us to test our hypotheses about the relationship (i.e. those with high RNT have poorer treatment outcomes and changes in RNT predict outcome across a range of anxiety and trauma disorders) and provide a basis for augmenting our existing treatments with interventions that specifically target this process.
Our sample consists of clients who have completed a course of CBT treatment from the Centre of Anxiety Disorders and Trauma between 01/01/2022 to 01/02/2024. Patients are typically seen for 12-20 sessions.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Change in Repetitive Ruminative Thinking Questionnaire score
Change in RTQ from pre- to post-treatment
Time frame: From pre treatment to post treatment for CBT at CADAT (an average of 12-20 weeks)
Change in disorder-specific measure score
Change in disorder-specific measure scores from pre- to post-treatment
Time frame: From pre treatment to post treatment for CBT at CADAT (an average of 12-20 weeks)
Ran from Jan 2022 to primary completion in Feb 2024, 25 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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South London and Maudsley NHS Foundation Trust