An interventional study of Project YES in Depression, Eating Disorders and Anxiety, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago. Completed at 1 site in United States. Open to participants aged 13 Years to 25 Years. Per ClinicalTrials.gov, last updated 2026-06-05.
Sponsored by Ann & Robert H Lurie Children's Hospital of Chicago · Not applicable, Interventional, and Treatment
This study tests a suite of single-session intervention (SSI) targeting risk factors for depression and eating disorders among adolescents and young adults. Youth ages 13-25 who screen positive for depression or anxiety as a part of routine care will be offered one of three digital SSIs. Participants will complete questionnaires before the intervention, immediately after the intervention, and 3-months after completing the intervention so that the study team can investigate if Project YES leads to reductions in depression, anxiety, as well as eating disorder symptoms.
8,057 studies on the registry are indexed under Depression; 1,641 are open to participants now.
This study's enrollment of 37 is below the median of 84 across 6,720 interventional studies indexed under Depression.
Browse Depression studies →Ann & Robert H Lurie Children's Hospital of Chicago is the lead sponsor of 176 studies on the registry; 30 are open to participants now.
Of its 10 completed or terminated interventional studies of FDA-regulated products, 5 (50%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
This is a digital, self-guided SSI that has 3 options, Project Personality, Project CARE, and the ABC project. These teach adolescents about CBT skills including growth mindset, neutral self-talk and behavioral activation. Each option contains self-reflection exercises, vignettes from fictional peers, and psychoeducation that support users in understanding each CBT skill. See all materials for this intervention here: https://www.schleiderlab.org/yes.html
Behavioral: Project YES
Digital SSI
Short Mood and Feelings Questionnaire (SMFQ; Messer et al., 1995)
A 13-item questionnaire designed to assess depressive symptoms in youth. Total scores range from 0 to 26, with higher scores indicating greater depression severity (primary outcome).
Time frame: Pre-Intervention (baseline), immediately after the intervention, 12-week follow-up
Patient Health Questionnaire-9 (PHQ-9)
A 9 item questionnaire that objectifies and assesses degree of depression severity. Total scores range from 0 to 27, with higher scores indicating greater depression severity.
Time frame: Pre-Intervention (baseline), 12-week follow-up
Generalized Anxiety Disorder -7 (GAD-7)
A 7 item questionnaire that measures severity of anxiety, mainly in outpatients. Total scores range from 0 to 21, with higher scores indicating greater anxiety severity.
Time frame: Pre-Intervention (baseline), 12-week follow-up
Dietary Restriction Screener - 2 (DRS 2)
This is a a single-item screener designed to identify individuals recently engaging in problematic restriction. The single item is "Have there been any times within the past month when you have eaten in this manner because you were concerned about your body shape and/or weight?" and has participants respond with a yes or a no.
Time frame: Pre-Intervention (baseline), immediately after the intervention, 12-week follow-up
Adult State Hope Scale
The 3-item State Hope Scale is a a dispositional self-report measure of agency. This scale can range from 3 to 24, with higher scores indicating higher levels of agency thinking.
Time frame: Pre-Intervention (baseline), immediately after the intervention, 12-week follow-up
Self-Hate Scale
The 7-item Self-Hate Scale is a brief, psychometrically valid measure of self-hate. Total scores are calculated as the mean of all items and scores are coded such that higher ratings indicate higher levels of self-hate (range 1-7).
Time frame: Pre-Intervention (baseline), immediately after the intervention, 12-week follow-up
Beck Hopelessness -4
This four-item scale measures major aspects of hopelessness using true/false questions examining the respondent's attitude for the past week. This scale ranges from 0-4 such that higher scores reflect higher levels of hopelessness.
Time frame: Pre-Intervention (baseline), immediately after the intervention, 12-week follow-up
Program Feedback Scale
The program feedback scale asks participants to rate agreement with seven statements indicating perceived acceptability and feasibility of their selected SSI (eg, "I enjoyed the program") on a 5-point Likert scale (1="really disagree"; 5="totally agree"). Means and standard deviations are calculated for each item (range 0-7), with a mean of 3.5 for each item indicating acceptability and feasibility.
Time frame: Immediately after the intervention
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Ann & Robert H Lurie Children's Hospital of Chicago