ClinicalTrials.gg
WithdrawnNCT06346873Updated Dec 18, 2025

Demonstrating Efficacy of JOGO for the Treatment of Tremor

An interventional study of JOGO in Functional Neurological Disorder, sponsored by Mayo Clinic. Withdrawn at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-18.

Sponsored by Mayo Clinic · Not applicable, Interventional, and Treatment

Why this study was withdrawn
PI No longer at Mayo Clinic
Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

This research is being done to determine the effectiveness of a new treatment, called JOGO, for patients with functional tremor (FT). JOGO is a biofeedback device that has been shown to help patients with several conditions, e.g., chronic pain, migraine, and Parkinson's disease (PD)-related tremor. JOGO provides biofeedback by using wireless adhesive stickers, called surface electromyography, to get information about muscle activity. This information is then used to modify symptoms through a series of training sessions with a physical therapist and individual practice.

02

Conditions studied

  • Functional Neurological Disorder

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Keywords

  • Functional Tremor
03

In context

Conversion Disorder

89 studies on the registry are indexed under Conversion Disorder; 34 are open to participants now.

Browse Conversion Disorder studies →

Lead sponsor

Mayo Clinic is the lead sponsor of 3,269 studies on the registry; 672 are open to participants now.

Of its 452 completed or terminated interventional studies of FDA-regulated products, 321 (71%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Clinical diagnosis of functional tremor diagnosed by a Mayo Clinic Florida movement disorders specialist.
  • Must have access to reliable internet video.

Exclusion criteria

Exclusion Criteria:

  • Cognitive impairment ( greater than 26).
  • Currently taking any of the following medications to treat tremor: primidone, gabapentin, zonisamide, any non-selective beta blocker, any benzodiazepine.
  • Exposure to tremorgenic drugs or drug with withdrawal states within 30 days prior to the study start.
  • Direct or indirect trauma to the nervous system within 3 months preceding the onset of tremor.
  • Known history of other medical or neurological conditions that may cause or explain subject's tremor, including, but not limited to: Parkinson's disease, dystonia, cerebellar disease, traumatic brain injury, alcohol abuse or withdrawal, mercury poisoning, hyperthyroidism, pheochromocytoma, head trauma or cerebrovascular disease within 3 months prior to the onset of essential tremor, multiple sclerosis, polyneuropathy, family history of Fragile X syndrome.
  • Prior MR-guided focused ultrasound or surgical intervention (e.g., deep brain stimulation, ablative thalamotomy or gamma knife thalamotomy).
  • Botulinum toxin injection in the 6 months prior to screening.
  • Use of medication(s) in the past month that might produce tremor or interfere with the evaluation of tremor, such as, but not limited to: CNS-stimulants, lithium, amiodarone, metoclopramide, theophylline, and valproate.
  • Regular use of more than two units of alcohol per day.
  • Sporadic use of a benzodiazepine, sleep medication or anxiolytic to improve sleep performance. Stable use at a consistent dose is allowed if tremor persists against the background of regular medication use.
  • Current treatment with any therapy for tremor.
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

MMSE and MoCA

Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.

Investigational drug or device

A drug or device being studied in a clinical trial.

It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    JOGO for the Treatment of Tremor

    Subjects with a diagnosis of essential tremor (ET) or functional tremor (FT) involving one or more of the upper extremities will undergo a 12-week JOGO treatment program.

    Device: JOGO

Interventions

  • DeviceJOGO

    AI driven mobile app and wearable sensors to provide virtual treatments

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What researchers measure

Primary outcomes

  1. Change in TETRAS scores 1 month

    Assessment with The Essential Tremor Rating Assessment Scale (TETRAS), consists of ten items in which action tremor is rated 0-4 in half-point increments by a clinician. Greater total scores indicate worse action tremor.

    Time frame: Baseline, 1-month post-treatment

Secondary outcomes

  1. Change in TETRAS scores 2 months

    Assessment with The Essential Tremor Rating Assessment Scale (TETRAS), consists of ten items in which action tremor is rated 0-4 in half-point increments by a clinician. Greater total scores indicate worse action tremor.

    Time frame: Baseline, 2-month post-treatment

  2. Change in QUEST scores

    Measured by self-assessment with the Quality of Life in Essential Tremor Questionnaire (QUEST)

    Time frame: Baseline, 1-month and 2-month post-treatment

  3. Tremor prevalence

    Number of tremors in time awake during the day measured by wearable device system (KinesiaUTM).

    Time frame: 2 months

  4. Tremor resolution 1 month

    Number of subjects to experience tremor resolution on in-lab assessment

    Time frame: 1-month post-treatment

  5. Tremor resolution 2 months

    Number of subjects to experience tremor resolution on in-lab assessment

    Time frame: 2-months post-treatment

  6. Change in BDI-II scores

    Assessment with the Beck Depression Index II (BDI-II) questionnaire to assess depression severity, a 21-item scale, with items ranging from 0 to 3. Total score of 0-13 is considered minimal range, 14-19 is mild, 20-28 is moderate, and 29-63 is severe.

    Time frame: Baseline, 1-month and 2-month post-treatment

  7. Change in BAI scores

    Assessment with the Beck Anxiety Index (BAI) that measures the severity of anxiety symptoms. Possible scores range from 0 to 63 with higher scores indicating a worse outcome/more severe symptoms of anxiety.

    Time frame: Baseline, 1-month and 2-month post-treatment

  8. Change in Intolerance of Uncertainty Scale

    Time frame: Baseline, 1-month and 2-month post-treatment

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Study locations

1 site
  • Mayo Clinic in Florida
    Jacksonville, Florida 32224, United States
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References and documents

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 18, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06346873
Lead sponsor
Mayo Clinic
Responsible party
Sponsor
First posted
Apr 4, 2024
Start date
Jan 3, 2025
Primary completion
Jan 3, 2025
Completion
Jan 3, 2025
Last update
Dec 18, 2025

Study contacts

Philip Tipton, MD
principal investigator · Mayo Clinic

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

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