An observational study in Type B Aortic Dissection, sponsored by Assiut University. Not yet recruiting at 1 site in Egypt. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2024-03-04.
Sponsored by Assiut University · Observational
Assess the clinical outcome, morphological changes and behaviour of type B aortic dissection after endovascular repair.
Aortic dissection (AD) is considered the most common catastrophic event of the aorta, and its incidence has been reported to be ≈3/100000 per year, exceeding that of ruptured abdominal aortic aneurysm.
AD is a dynamic process and can occur anywhere along the course of the aorta, with the pathognomonic lesion being an intimal tear followed by blood surging either antegrade (typically) or retrograde, cleaving the the intima and medial layers of the aortic wall longitudinally for a variable distance, thus creating a true and false lumens.
Aortic dissections are classified by chronicity, anatomic location of false lumen, generally the entry tear and longitudinal extent, and the presence or absence of complicating features.
Temporally, AD is categorized as acute phase {\<14 days}, subacute {15-90 days}, and chronic {>90 days}.
Thoracic Endovascular Aortic Repair (TEVAR) has emerged as the first-line therapy for the treatment of AD, with better short-term results than open repair due to a significant decrease in perioperative morbidity and mortality.
By covering the primary entry tear with stent-grafts, the blood flow is redirected into the true lumen, resolving malperfusion and/or preventing rupture of the false lumen, followed by its regression and re-expansion of the true lumen, which is known as "Aortic remodeling"
386 studies on the registry are indexed under Aortic Dissection; 117 are open to participants now.
This study's planned enrollment of 30 is below the median of 183 across 180 observational studies indexed under Aortic Dissection.
Browse Aortic Dissection studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
complicated or high-risk acute, subacute or chronic type B aortic dissection.
Complicated Stanford type B dissections:
High-risk aortic dissections:
Aortic anatomy suitable for stent graft therapy:
Exclusion Criteria:
minimally invasive endovascular intervention to treat aortic dissection
Analysis of aortic remodeling
evaluation of diameter changes between the preoperative and postoperative CTs measurements in millimetres . The true lumen index (Tli) is calcuated by dividing thr true lumen diameter by the whole lumen (transaortic) diameter. The fasle lumen index (Fli) is calculated in the same manner. The desirable TLi value approaches or equals 1 (suggesting increase in true lumen to normal), whereas the sought-after FLi value approaches or equals 0 (suggesting shrinkage in false lumen).
Time frame: 2 years
technical success
successful delivery and deployment of the device with coverage of the 1ry tear at implant with no detected endoleak on angiography
Time frame: baseline
This study is not yet recruiting, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.
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Assiut University