An observational study in Cerebral Lymphoma, sponsored by IRCCS San Raffaele. Recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-11.
Sponsored by IRCCS San Raffaele · Observational
Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non- Hodgkin lymphoma exclusively localized into the nervous system. The aim of this study is to evaluate the MRI imaging characteristics of the peritumoral area (PTA) and to correlate this information to pathological findings.
Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non- Hodgkin lymphoma exclusively localized into the nervous system. It is a relatively rare disorder, accounting for only 3% of all primary brain tumors but due to its anatomical localization represents an important clinical and diagnostic challenge in onco-hematology. different MRI patterns of the peritumoral area (PTA) might correlate with different histopathological sensitivity regarding diagnostic potential out of contrast-enhanced region (CER). Improvements in the understanding of PTA diagnostic potentials is of great help in diagnosing patients with deep-seated lesions, who would otherwise be not eligible for stereotactic biopsy and therefore for a consequent adequate treatment.
5,578 studies on the registry are indexed under Lymphoma; 825 are open to participants now.
This study's planned enrollment of 15 is below the median of 136 across 625 observational studies indexed under Lymphoma.
Browse Lymphoma studies →IRCCS San Raffaele is the lead sponsor of 443 studies on the registry; 234 are open to participants now.
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Adult patients, undergoing stereotactic biopsy for newly diagnosed PSNCLs at our Institution, able to express informed consent.
Exclusion Criteria:
Adult patients (\>18 years) candidates to stereotactic biopsy for histopathological diagnosis of intra-axial lesions suspected for primary central nervous system lymphoma (PCNSLs).
Diagnostic Test: MRI imaging · Diagnostic Test: Cerebral biopsy
To characterize the peritumoral area in PCNLs through the use of advanced MRI sequences.
To evaluate the predictive value of sodium fluorescence to confirm ex-vivo the diagnostic tumor tissue prior to histopathological examination.
MRI imaging
Peritumoral area (PTA) volumes in T1w sequence Units: cm3.
Time frame: Baseline (before surgery)
MRI imaging
Peritumoral area (PTA) volumes in T2w sequence. Units: cm3.
Time frame: Baseline (before surgery)
MRI imaging
Peritumoral area (PTA) volumes in FLAIR sequence. Units: cm3.
Time frame: Baseline (before surgery)
MRI imaging
Peritumoral area (PTA) mean ADC value in PTA. Units: mm2/s
Time frame: Baseline (before surgery)
Define immunopathological features
Number of immune cells infiltrating the lesion. Units: number/mm3
Time frame: 1 week after surgical procedure
Accuracy of fluoresceine guided stereotactic biopsy
Number of patients with samples positively stained with fluoresceine. Units: number of samples/patients
Time frame: 1 week after surgical procedure
Plan to share: No
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IRCCS San Raffaele