This Research Project Studies the Relationship Between OSA and Nocturia.

Browse trials for

• Apnea 1,424
• Sleep Apnea Syndromes 2,163
• Sleep Apnea, Obstructive 2,191
• Nocturia 124

Keywords

• Obstructive Sleep Apnea
• Nocturia
• Lower urinary tract symptoms
• Voiding diary
• Nocturnal polyuria

Study population

Groups and cohorts

• Patients with OSA

  Patients with diagnosed OSA will be included in this study group.

  Other: Voiding diary

Interventions

• OtherVoiding diary

  The patients with diagnosed OSA will be asked to fill in the voiding diary.

Primary outcomes

1. Change in the parameters of sleep apnoea - (apnea-hypopnea index - AHI)

   The change in parameters of sleep apnoea - apnea-hypopnea index (AHI) will be monitored from the baseline to the end of follow-up, before and after the treatment intervention for correction of obstructive sleep apnoea (OSA). The obtained data will be correlated with the information from the voiding diary. The apnea-hypopnea index (AHI) is the combined average number of apneas and hypopneas that occur per hour of sleep. According to the American Academy of Sleep Medicine (AASM) it is categorized into mild (5-15 events/hour), moderate (15-30 events/hour), and severe (\> 30 events/hour).ollow-up, before and after the treatment intervention for correction of obstructive sleep apnoea (OSA). The obtained data will be correlated with the information from the voiding diary.

   Time frame: 3 months

2. Change in the parameters of sleep apnoea - oxygen desaturation index (ODI)

   The change in parameters of sleep apnoea - oxygen desaturation index (ODI) will be monitored from the baseline to the end of follow-up, before and after the treatment intervention for correction of obstructive sleep apnoea (OSA). The obtained data will be correlated with the information from the voiding diary. ODI refers to the average number of desaturation episodes occurring per hour, where desaturation episodes are defined as a decrease in the mean oxygen saturation of ≥3% (over the last 120 seconds) that lasts for at least 10 seconds.

   Time frame: 3 months

3. Change in the parameters of sleep apnoea - time under 90% saturation (T90)

   The change in parameters of sleep apnoea - time under 90% saturation (T90) will be monitored from the baseline to the end of follow-up, before and after the treatment intervention for correction of obstructive sleep apnoea (OSA). The obtained data will be correlated with the information from the voiding diary. T90 was defined as the proportion of cumulative sleep time with oxygen saturation below 90% in total sleep time. T90≤5% of the total sleep time was classified as light hypoxia, T90 of 5-10% as mild hypoxia,10-25% as moderate hypoxia, and \>25% as severe hypoxia.

   Time frame: 3 months

Secondary outcomes

1. Change in the data from the voiding diary - functional capacity of the bladder

   The change in bladder-derived parameters will be monitored from the baseline to the end of follow-up - functional capacity of the bladder will be measured in milliliters (mL).

   Time frame: 3 months

2. Change in the data from the voiding diary - daily diuresis

   The change in bladder-derived parameters will be monitored from the baseline to the end of follow-up - daily diuresis will be measured in milliliters (mL).

   Time frame: 3 months

3. Change in the data from the voiding diary - number of voiding episodes

   The change in bladder-derived parameters will be monitored from the baseline to the end of follow-up - the number of voiding episodes during sleep will be counted and monitored.

   Time frame: 3 months

Publications

• Berry RB, Brooks R, Gamaldo C, Harding SM, Lloyd RM, Quan SF, Troester MT, Vaughn BV. AASM Scoring Manual Updates for 2017 (Version 2.4). J Clin Sleep Med. 2017 May 15;13(5):665-666. doi: 10.5664/jcsm.6576. No abstract available. PubMed 28416048 ↗
• Lowenstein L, Kenton K, Brubaker L, Pillar G, Undevia N, Mueller ER, FitzGerald MP. The relationship between obstructive sleep apnea, nocturia, and daytime overactive bladder syndrome in women. Am J Obstet Gynecol. 2008 May;198(5):598.e1-5. doi: 10.1016/j.ajog.2008.02.024. PubMed 18455544 ↗
• Oztura I, Kaynak D, Kaynak HC. Nocturia in sleep-disordered breathing. Sleep Med. 2006 Jun;7(4):362-7. doi: 10.1016/j.sleep.2005.10.004. Epub 2006 Mar 24. PubMed 16564213 ↗
• Umlauf MG, Chasens ER, Greevy RA, Arnold J, Burgio KL, Pillion DJ. Obstructive sleep apnea, nocturia and polyuria in older adults. Sleep. 2004 Feb 1;27(1):139-44. doi: 10.1093/sleep/27.1.139. PubMed 14998251 ↗
• Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993 Apr 29;328(17):1230-5. doi: 10.1056/NEJM199304293281704. PubMed 8464434 ↗

Individual participant data

Plan to share: No — There is no plan to share the individual participant data with other researchers.