An observational study in PSVD With or Without SSc, sponsored by University Hospital, Caen. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-06-20.
Sponsored by University Hospital, Caen · Observational
Porto-Sinusoidal Vascular Disorders (PSVD) is a heterogeneous clinico-pathological entity characterized by alterations in small liver vessels. "Nodular regenerative hyperplasia (NRH)" is the most common PSVD. The most frequent liver disease associated with Systemic sclerosis (SSc) is primary biliary cholangitis reported in 2 to 22% of cases. NRH prevalence estimated to 1.4%, may be underestimated as NRH diagnosis is histologic and usually suspected in case of complications due to portal hypertension. Few data are available about NRH associated with SSc resulting in a lack of knowledge of the characteristics and outcome of these patients.
The study aims to compare the outcome of patients with MVPS associated with SSc to patients with MVPS without SSc. This work is a multicenter retrospective study comparing two groups of adult patients, one with MVPS associated with SSc and the other with MVPS without SSc. Patients with MVPS associated with SSc will be recruited from French university hospital departments of Hepatogastroenterology and Internal Medecine. Patients with MVPS without SSc will be recruited from the Beaujon Hospital database dedicated to liver vascular diseases.
695 studies on the registry are indexed under Scleroderma, Systemic; 224 are open to participants now.
This study's enrollment of 180 is above the median of 100 across 171 observational studies indexed under Scleroderma, Systemic.
Browse Scleroderma, Systemic studies →University Hospital, Caen is the lead sponsor of 510 studies on the registry; 80 are open to participants now.
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3 types of patients : PSVD with SSC, PSVD without SSC, SSC without PSVD will be compared.
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Exclusion Criteria:
medical file analysis of patients affected by SSC and PSVD
medical file analysis of patients affected by PSVD only
medical file analysis of patients affected by SSC only
Prognosis
To compare prognosis of PSVD patients with or without SSc (less or more gastrointestinal bleeding/portal vein thrombosis)
Time frame: 2 years
This study is completed, as verified in Mar 2024. You cannot join it, but the record below documents what was studied.
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